Structure and steroid isomerase activity of Drosophila glutathione transferase E14 essential for ecdysteroid biosynthesis
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13718
Abstract: Ecdysteroids are critically important for the formation of the insect exoskeleton. Cholesterol is a precursor of ecdysone and its active form 20‐hydroxyecdysone, but some steps in the ecdysteroid biosynthesis pathway remain unknown. An essential requirement… read more here.
Keywords: isomerase activity; biosynthesis; transferase; ecdysteroid biosynthesis ... See more keywords
Overexpression of BcERF3 increases biosynthesis of saikosaponins in Bupleurum chinense.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS open bio"
DOI: 10.1002/2211-5463.13412
Abstract: Chaihu, the dried roots of some species of Bupleurum L., is a famous Chinese herbal medicine for treatment of liver- and cold- related diseases, in which saikosaponins (SSs) are the major active compounds. Many of… read more here.
Keywords: overexpression bcerf3; bcerf3 increases; biosynthesis saikosaponins; biosynthesis ... See more keywords
Construction of an Alternative NAD+ De Novo Biosynthesis Pathway
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DOI: 10.1002/advs.202004632
Abstract: Abstract Nicotinamide adenine dinucleotide (NAD+) is a life essential molecule involved in versatile biological processes. To date, only two de novo biosynthetic routes to NAD+ are described, both of which start from a proteinogenic amino… read more here.
Keywords: biosynthesis; nad novo; alternative nad; c3n pathway ... See more keywords
Whole‐Cell P450 Biocatalysis Using Engineered Escherichia coli with Fine‐Tuned Heme Biosynthesis (Adv. Sci. 6/2023)
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DOI: 10.1002/advs.202205580
Abstract: By exploiting versatile P450 enzymes, whole‐cell biocatalysis can be performed to synthesize valuable compounds in Escherichia coli. However, the insufficient supply of heme limits the whole‐cell P450 biocatalytic activity. Here a strategy for improving intracellular… read more here.
Keywords: biosynthesis; fine tuned; heme biosynthesis; whole cell ... See more keywords
Unraveling Tissue‐Specific Fatty Acid Biosynthesis and Inter‐Tissue Crosstalk in Mice through Stable‐Isotope Tracing Metabolomics
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DOI: 10.1002/advs.202503662
Abstract: Biosynthesis of free fatty acids (FFAs) in mammals is pivotal for metabolic homeostasis, yet a comprehensive understanding of tissue‐specific biosynthesis and inter‐tissue crosstalk of FFAs remains incomplete. In vivo stable‐isotope tracing metabolomics is utilized to… read more here.
Keywords: inter tissue; tissue crosstalk; biosynthesis; tissue specific ... See more keywords
Engineered Fusion Enzyme‐Mediated Non‐Consecutive Cyclization‐Glycosylation Enables Heterologous Synthesis of Antifungal Enfumafungin
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DOI: 10.1002/advs.202507531
Abstract: Enfumafungin‐type antibiotics, represented by enfumafungin and fuscoatroside, constitute a distinct class of fungi‐derived fernane‐type triterpenoids renowned for their potent antifungal activity. Notably, ibrexafungerp, a semi‐chemically synthesized analogue of enfumafungin, has recently received approval as a… read more here.
Keywords: fusion; enfumafungin; biosynthesis; non consecutive ... See more keywords
Genome-scale Metabolic Modeling Guided Escherichia coli Engineering for De Novo Biosynthesis of Chrysanthemic Acid.
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DOI: 10.1002/advs.202512736
Abstract: Chrysanthemic acid is an unconventional monoterpene moiety of the natural pesticide pyrethrins with notable anti‐insect activity, making its industrial biosynthesis a promising avenue for sustainable agriculture. Here, an E. coli cell factory is designed and… read more here.
Keywords: genome scale; chrysanthemic acid; coli; biosynthesis ... See more keywords
Jasmonic acid‐responsive AabHLH1 positively regulates artemisinin biosynthesis in Artemisia annua
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1733
Abstract: Artemisia annua is the only natural source of the sesquiterpenoid artemisinin, which is widely used to treat malaria. The phytohormone jasmonic acid (JA) can significantly promote artemisinin biosynthesis in A. annua. AabHLH1 can bind and… read more here.
Keywords: biosynthesis; artemisinin biosynthesis; jasmonic acid; artemisia annua ... See more keywords
Biosynthesis and antibiotic activity of silver nanoparticles using different sources: Glass industrial sewage‐adapted Bacillus sp. and herbaceous Amaranthus sp
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1803
Abstract: Synergistic effects of metallic nanoparticles (NPs) with commonly used antibiotics have encouraged the exploration of novel biological entities, including bacteria and weed plants. The present study for the first time reports the capability of an… read more here.
Keywords: silver nanoparticles; biosynthesis; biosynthesis antibiotic; antibiotic activity ... See more keywords
A sustainable strategy for biosynthesis of Rebaudioside D using a novel glycosyltransferase of Solanum tuberosum
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DOI: 10.1002/biot.202300628
Abstract: Bioconversion of Rebaudioside D faces high‐cost obstacles. Herein, a novel glycosyltransferase StUGT converting Rebaudioside A to Rebaudioside D was screened and characterized, which exhibits stronger affinity and substrate specificity for Rebaudioside A than previously reported… read more here.
Keywords: rebaudioside; biosynthesis; novel glycosyltransferase; cell ... See more keywords
Genome‐Scale Metabolic Modeling of Halomonas elongata 153B Explains Polyhydroxyalkanoate and Ectoine Biosynthesis in Hypersaline Environments
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DOI: 10.1002/biot.202400267
Abstract: Halomonas elongata thrives in hypersaline environments producing polyhydroxyalkanoates (PHAs) and osmoprotectants such as ectoine. Despite its biotechnological importance, several aspects of the dynamics of its metabolism remain elusive. Here, we construct and validate a genome‐scale… read more here.
Keywords: genome scale; biosynthesis; halomonas elongata; hypersaline environments ... See more keywords