Structure and steroid isomerase activity of Drosophila glutathione transferase E14 essential for ecdysteroid biosynthesis
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13718
Abstract: Ecdysteroids are critically important for the formation of the insect exoskeleton. Cholesterol is a precursor of ecdysone and its active form 20‐hydroxyecdysone, but some steps in the ecdysteroid biosynthesis pathway remain unknown. An essential requirement… read more here.
Keywords: isomerase activity; biosynthesis; transferase; ecdysteroid biosynthesis ... See more keywords
Overexpression of BcERF3 increases biosynthesis of saikosaponins in Bupleurum chinense.
Sign Up to like & getrecommendations! Published in 2022 at "FEBS open bio"
DOI: 10.1002/2211-5463.13412
Abstract: Chaihu, the dried roots of some species of Bupleurum L., is a famous Chinese herbal medicine for treatment of liver- and cold- related diseases, in which saikosaponins (SSs) are the major active compounds. Many of… read more here.
Keywords: overexpression bcerf3; bcerf3 increases; biosynthesis saikosaponins; biosynthesis ... See more keywords
Construction of an Alternative NAD+ De Novo Biosynthesis Pathway
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DOI: 10.1002/advs.202004632
Abstract: Abstract Nicotinamide adenine dinucleotide (NAD+) is a life essential molecule involved in versatile biological processes. To date, only two de novo biosynthetic routes to NAD+ are described, both of which start from a proteinogenic amino… read more here.
Keywords: biosynthesis; nad novo; alternative nad; c3n pathway ... See more keywords
Whole‐Cell P450 Biocatalysis Using Engineered Escherichia coli with Fine‐Tuned Heme Biosynthesis (Adv. Sci. 6/2023)
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DOI: 10.1002/advs.202205580
Abstract: By exploiting versatile P450 enzymes, whole‐cell biocatalysis can be performed to synthesize valuable compounds in Escherichia coli. However, the insufficient supply of heme limits the whole‐cell P450 biocatalytic activity. Here a strategy for improving intracellular… read more here.
Keywords: biosynthesis; fine tuned; heme biosynthesis; whole cell ... See more keywords
Jasmonic acid‐responsive AabHLH1 positively regulates artemisinin biosynthesis in Artemisia annua
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1733
Abstract: Artemisia annua is the only natural source of the sesquiterpenoid artemisinin, which is widely used to treat malaria. The phytohormone jasmonic acid (JA) can significantly promote artemisinin biosynthesis in A. annua. AabHLH1 can bind and… read more here.
Keywords: biosynthesis; artemisinin biosynthesis; jasmonic acid; artemisia annua ... See more keywords
Biosynthesis and antibiotic activity of silver nanoparticles using different sources: Glass industrial sewage‐adapted Bacillus sp. and herbaceous Amaranthus sp
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1803
Abstract: Synergistic effects of metallic nanoparticles (NPs) with commonly used antibiotics have encouraged the exploration of novel biological entities, including bacteria and weed plants. The present study for the first time reports the capability of an… read more here.
Keywords: silver nanoparticles; biosynthesis; biosynthesis antibiotic; antibiotic activity ... See more keywords
Coupling riboflavin de novo biosynthesis and cytochrome expression for improving extracellular electron transfer efficiency in Shewanella oneidensis
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DOI: 10.1002/bit.28172
Abstract: Shewanella oneidensis MR‐1, as a model exoelectrogen with divergent extracellular electron transfer (EET) pathways, has been widely used in microbial fuel cells (MFCs). The electron transfer rate is largely determined by riboflavin (RF) and c‐type… read more here.
Keywords: novo biosynthesis; biosynthesis; expression; electron transfer ... See more keywords
Regulating substrate preference of phosphatase by reshaping the “cap domain” for multi‐enzymatic biosynthesis of high‐purity monosaccharides
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DOI: 10.1002/bit.28244
Abstract: Phosphatases are a class of enzymes catalyzing the cleavage of monophosphate ester bonds from the phosphorylated substrates. They have important applications in construction of in vitro multi‐enzymatic system for monosaccharides. However, the enzymes generally show… read more here.
Keywords: biosynthesis; cap domain; multi enzymatic; high purity ... See more keywords
Biosynthesis of geranate via isopentenol utilization pathway in Escherichia coli
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DOI: 10.1002/bit.28255
Abstract: Isoprenoids are a large family of natural products with diverse structures, which allow them to play diverse and important roles in the physiology of plants and animals. They also have important commercial uses as pharmaceuticals,… read more here.
Keywords: geranate; biosynthesis; escherichia coli; isopentenol utilization ... See more keywords
Targeted Rediscovery and Biosynthesis of the Farnesyl‐Transferase Inhibitor Pepticinnamin E
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DOI: 10.1002/cbic.201900025
Abstract: The natural product pepticinnamin E potently inhibits protein farnesyl transferases and has potential applications in treating cancer and malaria. Pepticinnamin E contains a rare N‐terminal cinnamoyl moiety as well as several nonproteinogenic amino acids, including the unusual… read more here.
Keywords: pepticinnamin; rediscovery biosynthesis; biosynthesis; biosynthesis farnesyl ... See more keywords
Understanding the Glycopeptide Antibiotic Crosslinking Cascade: In Vitro Approaches Reveal the Details of a Complex Biosynthesis Pathway
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DOI: 10.1002/cbic.202000309
Abstract: The glycopeptide antibiotics (GPAs) are a fascinating example of complex natural product biosynthesis, with the nonribosomal synthesis of the peptide core coupled to a cytochrome P450‐mediated cyclisation cascade that crosslinks aromatic side chains within this… read more here.
Keywords: crosslinking cascade; biosynthesis; antibiotic crosslinking; cascade ... See more keywords