Early Steps of the Biosynthesis of the Anticancer Antibiotic Pleurotin
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DOI: 10.1021/acschembio.4c00599
Abstract: Pleurotin is a meroterpenoid specialised metabolite made by the fungus Hohenbuehelia grisea, and it is a lead anticancer molecule due to its irreversible inhibition of the thioredoxin-thioredoxin reductase system. Total synthesis of pleurotin has previously… read more here.
Keywords: early steps; anticancer antibiotic; biosynthesis anticancer; steps biosynthesis ... See more keywords
De Novo Biosynthesis of the Anticancer Compound Euphol in Saccharomyces cerevisiae.
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DOI: 10.1021/acssynbio.1c00257
Abstract: Euphol is a euphane-type tetracyclic triterpene which is primarily found in the Euphorbia genus. Euphol has been renowned because of its great potential as a promising anticancer drug. Surprisingly, despite its diverse antitumor effects, the… read more here.
Keywords: euphol; saccharomyces cerevisiae; biosynthesis anticancer; novo biosynthesis ... See more keywords
Biosynthesis of anticancer phytochemical compounds and their chemistry
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1136779
Abstract: Cancer is a severe health issue, and cancer cases are rising yearly. New anticancer drugs have been developed as our understanding of the molecular mechanisms behind diverse solid tumors, and metastatic malignancies have increased. Plant-derived… read more here.
Keywords: phytochemical compounds; chemistry; biosynthesis anticancer; cancer ... See more keywords