Diversity and evolution of polyketide biosynthesis gene clusters in the Ceratocystidaceae.
Sign Up to like & getrecommendations! Published in 2018 at "Fungal biology"
DOI: 10.1016/j.funbio.2018.04.011
Abstract: Polyketides are secondary metabolites with diverse biological activities. Polyketide synthases (PKS) are often encoded from genes clustered in the same genomic region. Functional analyses and genomic studies show that most fungi are capable of producing… read more here.
Keywords: gene clusters; biology; polyketide biosynthesis; biosynthesis gene ... See more keywords
Identification of a putative FR901469 biosynthesis gene cluster in fungal sp. No. 11243 and enhancement of the productivity by overexpressing the transcription factor gene frbF.
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DOI: 10.1016/j.jbiosc.2016.08.007
Abstract: FR901469 is an antifungal antibiotic produced by fungal sp. No. 11243. Here, we searched for FR901469 biosynthesis genes in the genome of No. 11243. Based on the molecular structure of FR901469 and endogenous functional motifs… read more here.
Keywords: biosynthesis; fr901469 biosynthesis; biosynthesis gene; putative fr901469 ... See more keywords
The Swinholide Biosynthesis Gene Cluster from a Terrestrial Cyanobacterium, Nostoc sp. Strain UHCC 0450
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DOI: 10.1128/aem.02321-17
Abstract: ABSTRACT Swinholides are 42-carbon ring polyketides with a 2-fold axis of symmetry. They are potent cytotoxins that disrupt the actin cytoskeleton. Swinholides were discovered from the marine sponge Theonella sp. and were long suspected to… read more here.
Keywords: strain uhcc; biosynthesis; biosynthesis gene; uhcc 0450 ... See more keywords