Biosynthesis-Guided Discovery and Engineering of α-Pyrone Natural Products from Type I Polyketide Synthases
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DOI: 10.1021/acschembio.3c00081
Abstract: Natural products containing the α-pyrone moiety are produced by polyketide synthases (PKSs) in bacteria, fungi, and plants. The conserved biosynthetic logic for the production of the α-pyrone moiety involves the cyclization of a triketide intermediate… read more here.
Keywords: biosynthesis guided; pyrone; natural products; natural product ... See more keywords