Directed Biosynthesis of Iso-aclacinomycins with Improved Anticancer Activity.
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DOI: 10.1021/acs.orglett.9b04069
Abstract: A four-enzyme catalyzed hydroxy regioisomerization of anthracycline was integrated into the biosynthetic pathway of aclacinomycin A (ALM-A), to generate a series of iso-ALMs via directed combinatorial biosynthesis combined with precursor-directed mutasynthesis. Most of the newly… read more here.
Keywords: biosynthesis iso; biosynthesis; iso; iso alms ... See more keywords