Biosynthesis of Nonimmunosuppressive ProlylFK506 Analogues with Neurite Outgrowth and Synaptogenic Activity.
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DOI: 10.1021/acs.jnatprod.0c00767
Abstract: Separating the immunosuppressive activity of FK506 (1) from its neurotrophic activity is required to develop FK506 analogues as drugs for the treatment of neuronal diseases. Two new FK506 analogues, 9-deoxo-36,37-dihydro-prolylFK506 (2) and 9-deoxo-31-O-demethyl-36,37-dihydro-prolylFK506 (3) containing… read more here.
Keywords: biosynthesis nonimmunosuppressive; neurite outgrowth; prolylfk506; nonimmunosuppressive prolylfk506 ... See more keywords
Biosynthesis of Nonimmunosuppressive FK506 Analogues with Antifungal Activity.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.9b00144
Abstract: A reduction in the strong immunosuppressive activity of FK506 (1) is essential for developing this compound as an antifungal agent. Seven new FK506 analogues modified at both the FK506-binding protein 12- and the calcineurin-binding regions… read more here.
Keywords: biosynthesis nonimmunosuppressive; fk506 analogues; antifungal activity; activity ... See more keywords