Comparative transcriptomic analysis of genes in the triterpene saponin biosynthesis pathway in leaves and roots of Ardisia kteniophylla A. DC., a plant used in traditional Chinese medicine
Sign Up to like & getrecommendations! Published in 2022 at "Ecology and Evolution"
DOI: 10.1002/ece3.8920
Abstract: Abstract Ardisia kteniophylla (Primulaceae) is highly valued in traditional medicine due to its production of the pharmacologically active secondary metabolites, especially triterpenoid saponins in its roots. Although A. kteniophylla is very important in traditional medicine,… read more here.
Keywords: biosynthesis; saponin biosynthesis; kteniophylla; triterpenoid saponins ... See more keywords
Understanding the riboflavin biosynthesis pathway for the development of antimicrobial agents
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DOI: 10.1002/med.21576
Abstract: Life on earth depends on the biosynthesis of riboflavin, which plays a vital role in biological electron transport processes. Higher mammals obtain riboflavin from dietary sources; however, various microorganisms, including Gram‐negative pathogenic bacteria and yeast,… read more here.
Keywords: biosynthesis; riboflavin biosynthesis; understanding riboflavin; biosynthesis pathway ... See more keywords
Putative pheromone biosynthesis pathway in Maruca vitrata by transcriptomic analysis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Asia-pacific Entomology"
DOI: 10.1016/j.aspen.2016.12.008
Abstract: Abstract Pheromone biosynthesis in the pheromone gland is stimulated by pheromone biosynthesis activating neuropeptide (PBAN) produced in the suboesophageal ganglion. PBAN binds its receptor and transduces biological signal into the molecules for the pheromone biosynthesis.… read more here.
Keywords: biosynthesis pathway; biosynthesis; pheromone; coa ... See more keywords
Agrobacterium rhizogenes-mediated RNAi of Tripterygium wilfordii and application for functional study of terpenoid biosynthesis pathway genes
Sign Up to like & getrecommendations! Published in 2019 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2019.111509
Abstract: Abstract Tripterygium wilfordii is an important medical plants which is rich in several valuable bioactive terpenoids, such as triptolide and wilforine. Developing a fast and efficient transformation method is imperative for exploring these metabolites biosynthesis… read more here.
Keywords: biosynthesis pathway; tripterygium; tripterygium wilfordii; agrobacterium rhizogenes ... See more keywords
Discovery of the Lead Molecules Targeting the First Step of the Histidine Biosynthesis Pathway of Acinetobacter baumannii
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DOI: 10.1021/acs.jcim.1c01421
Abstract: Acinetobacter baumannii is a multidrug-resistant, opportunistic, nosocomial pathogen for which a new line of treatments is desperately needed. We have targeted the enzyme of the first step of the histidine biosynthesis pathway, viz., ATP-phosphoribosyltransferase (ATP-PRT).… read more here.
Keywords: step histidine; histidine biosynthesis; first step; acinetobacter baumannii ... See more keywords
Rapid Inhibition Profiling Identifies a Keystone Target in the Nucleotide Biosynthesis Pathway.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.8b00273
Abstract: Understanding the mechanism of action (MOA) of new antimicrobial agents is a critical step in drug discovery but is notoriously difficult for compounds that appear to inhibit multiple cellular pathways. We recently described image-based approaches… read more here.
Keywords: biosynthesis; biosynthesis pathway; nucleotide biosynthesis; dna replication ... See more keywords
A non-natural biosynthesis pathway toward 2-methylisoborneol.
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DOI: 10.1039/d2cc00636g
Abstract: The biosynthesis of 2-methylisoborneol was reconstituted by elongation of dimethylallyl diphosphate (DMAPP) with (S)- and (R)-2-methylisopentenyl diphosphate (2-Me-IPP) using farnesyl diphosphate synthase (FPPS), followed by terpene cyclisation. The stereochemical course of the FPPS reaction was… read more here.
Keywords: biosynthesis; methylisoborneol; natural biosynthesis; pathway toward ... See more keywords
Genes and evolutionary fates of the amanitin biosynthesis pathway in poisonous mushrooms
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2201113119
Abstract: Significance Why do unrelated poisonous mushrooms (Amanita, Galerina, and Lepiota) make the same deadly toxin, α-amanitin? One of the most effective and fast strategies for organisms to acquire new abilities is through horizontal gene transfer… read more here.
Keywords: poisonous mushrooms; fates amanitin; genes evolutionary; amanitin biosynthesis ... See more keywords
Exopolysaccharides synthesized by lactic acid bacteria: biosynthesis pathway, structure-function relationship, structural modification and applicability.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in food science and nutrition"
DOI: 10.1080/10408398.2022.2043822
Abstract: Probiotics and their fermentation products are increasingly been focused on due to their health-boosting effects. Exopolysaccharides (EPS) synthetized by lactic acid bacteria (LAB) are widely applied as texture modifiers in dairy, meat and bakery products… read more here.
Keywords: biosynthesis pathway; structure function; relationship; function relationship ... See more keywords
Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24‐dehydrocholesterol reductase
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Internal Medicine"
DOI: 10.1111/joim.13095
Abstract: We have earlier reported that amiodarone, a potent and commonly used antiarrhythmic drug increases serum desmosterol, the last precursor of cholesterol, in 20 cardiac patients by an unknown mechanism. read more here.
Keywords: biosynthesis pathway; desmosterol; amiodarone disrupts; pathway causes ... See more keywords
Genetic architecture underlying the lignin biosynthesis pathway involves noncoding RNAs and transcription factors for growth and wood properties in Populus
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DOI: 10.1111/pbi.12978
Abstract: Summary Lignin provides structural support in perennial woody plants and is a complex phenolic polymer derived from phenylpropanoid pathway. Lignin biosynthesis is regulated by coordinated networks involving transcription factors (TFs), microRNAs (miRNAs) and long noncoding… read more here.
Keywords: growth wood; lignin biosynthesis; biosynthesis pathway; wood ... See more keywords