Bioinformatic Analysis Reveals both Oversampled and Underexplored Biosynthetic Diversity in Nonribosomal Peptides
Sign Up to like & getrecommendations! Published in 2023 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.2c00761
Abstract: The traditional natural product discovery approach has accessed only a fraction of the chemical diversity in nature. The use of bioinformatic tools to interpret the instructions encoded in microbial biosynthetic genes has the potential to… read more here.
Keywords: prediction algorithms; biosynthetic diversity; bioinformatic analysis; diversity ... See more keywords
A computational framework to explore large-scale biosynthetic diversity
Sign Up to like & getrecommendations! Published in 2019 at "Nature chemical biology"
DOI: 10.1038/s41589-019-0400-9
Abstract: Genome mining has become a key technology to exploit natural product diversity. Although initially performed on a single-genome basis, the process is now being scaled up to mine entire genera, strain collections and microbiomes. However,… read more here.
Keywords: diversity; framework; biosynthetic diversity; big scape ... See more keywords
Secondary metabolite biosynthetic diversity in Arctic Ocean metagenomes.
Sign Up to like & getrecommendations! Published in 2021 at "Microbial genomics"
DOI: 10.1099/mgen.0.000731
Abstract: Polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs) are mega enzymes responsible for the biosynthesis of a large fraction of natural products (NPs). Molecular markers for biosynthetic genes, such as the ketosynthase (KS) domain of… read more here.
Keywords: diversity; biosynthetic diversity; biosynthetic genes; arctic ocean ... See more keywords
Small Spatial Scale Drivers of Secondary Metabolite Biosynthetic Diversity in Environmental Microbiomes
Sign Up to like & getrecommendations! Published in 2023 at "mSystems"
DOI: 10.1128/msystems.00724-22
Abstract: To counteract the antibiotic resistance crisis, novel anti-infective agents need to be discovered and brought to market. Microbial secondary metabolites have been important sources of inspiration for small-molecule therapeutics. ABSTRACT In the search for novel… read more here.
Keywords: environmental microbiomes; spatial scale; small spatial; biosynthetic diversity ... See more keywords
The Secondary Metabolites and Biosynthetic Diversity From Aspergillus ochraceus
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.938626
Abstract: Aspergillus ochraceus, generally known as a food spoilage fungus, is the representative species in Aspergillus section Circumdati. A. ochraceus strains are widely distributed in nature, and usually isolated from cereal, coffee, fruit, and beverage. Increasing… read more here.
Keywords: metabolites biosynthetic; aspergillus ochraceus; biosynthetic diversity; secondary metabolites ... See more keywords