Corrigendum: Biosynthetic Gene Cluster for Surugamide A Encompasses an Unrelated Decapeptide, Surugamide F
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DOI: 10.1002/cbic.201700401
Abstract: The absolute configuration of the 3-amino-2-methyl propionic acid (AMPA) residue in surugamide F was assigned incorrectly, because the supplier erroneously provided the l-3-aminoisobutyric acid as d-3-aminoisobutyric acid and vice versa. Therefore, the absolute configuration of… read more here.
Keywords: surugamide; corrigendum biosynthetic; gene cluster; surugamide encompasses ... See more keywords
Identifying the Biosynthetic Gene Cluster for Triacsins with an N‐Hydroxytriazene Moiety
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DOI: 10.1002/cbic.201800762
Abstract: Triacsins are a family of natural products having in common an N‐hydroxytriazene moiety not found in any other known secondary metabolites. Though many studies have examined the biological activity of triacsins in lipid metabolism, their… read more here.
Keywords: biosynthetic gene; gene; hydroxytriazene moiety; gene cluster ... See more keywords
Identification of Oral Bacterial Biosynthetic Gene Clusters Associated with Caries.
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DOI: 10.1007/978-1-0716-1518-8_10
Abstract: Small molecules are a primary communication media of the microbial world, and play crucial, yet largely unidentified, roles in microbial ecology and disease pathogenesis. Many small molecules are produced by biosynthetic gene clusters, which can… read more here.
Keywords: identification oral; oral bacterial; biosynthetic gene; gene clusters ... See more keywords
Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-09708-z
Abstract: Secondary metabolites (SM) produced by fungi and bacteria have long been of exceptional interest owing to their unique biomedical ramifications. The traditional discovery of new natural products that was mainly driven by bioactivity screening has… read more here.
Keywords: detecting prioritizing; prioritizing biosynthetic; biosynthetic gene; gene clusters ... See more keywords
A chromatogram-simplified Streptomyces albus host for heterologous production of natural products
Sign Up to like & getrecommendations! Published in 2019 at "Antonie Van Leeuwenhoek"
DOI: 10.1007/s10482-019-01360-x
Abstract: Cloning natural product biosynthetic gene clusters from cultured or uncultured sources and their subsequent expression by genetically tractable heterologous hosts is an essential strategy for the elucidation and characterisation of novel microbial natural products. The… read more here.
Keywords: streptomyces albus; natural products; chromatogram simplified; simplified streptomyces ... See more keywords
nonG, a constituent of the nonactin biosynthetic gene cluster, regulates nocardamine synthesis in Streptomyces albus J1074.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.06.098
Abstract: Many factors regulate the expression of specialised secondary metabolite biosynthetic gene clusters, which have been recognised as important for the discovery of novel microbial natural products. A cosmid library based on genomic DNA of the… read more here.
Keywords: albus j1074; gene cluster; biosynthetic gene; gene ... See more keywords
Epigenetic modulations of mycoendophytes for novel bioactive molecules
Sign Up to like & getrecommendations! Published in 2018 at "Biocatalysis and agricultural biotechnology"
DOI: 10.1016/j.bcab.2018.09.025
Abstract: Abstract The need for new analogues with higher efficacy to combat the multidrug-resistant microbes as well as other health implications is the need of the hour. Medicinal chemistry has been focused highly in this regard… read more here.
Keywords: mycoendophytes novel; modulations mycoendophytes; novel bioactive; biosynthetic gene ... See more keywords
CRAGE-CRISPR facilitates rapid activation of secondary metabolite biosynthetic gene clusters in bacteria.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.08.009
Abstract: With the advent of genome sequencing and mining technologies, secondary metabolite biosynthetic gene clusters (BGCs) within bacterial genomes are becoming easier to predict. For subsequent BGC characterization, clustered regularly interspaced short palindromic repeats (CRISPR) has… read more here.
Keywords: crage; secondary metabolite; crage crispr; biosynthetic gene ... See more keywords
Characterization of the secondary metabolite biosynthetic gene clusters in archaea
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DOI: 10.1016/j.compbiolchem.2018.11.019
Abstract: Secondary metabolites are a range of bioactive compounds yielded by bacteria, fungi and plants, etc. The published archaea genomic data provide the opportunity for efficient identification of secondary metabolite biosynthetic gene clusters (BGCs) by genome… read more here.
Keywords: biosynthetic gene; gene clusters; secondary metabolite; metabolite biosynthetic ... See more keywords
Challenges of functional expression of complex polyketide biosynthetic gene clusters.
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DOI: 10.1016/j.copbio.2020.12.007
Abstract: Polyketide natural products are valuable sources of bioactive molecules such as nutraceuticals and pharmaceuticals. The tremendous development of the genome sequence database revealed that the majority of the biosynthetic gene clusters (BGCs) are cryptic. Activation… read more here.
Keywords: biosynthetic gene; gene clusters; challenges functional; functional expression ... See more keywords
Heterologous expression of cryptic biosynthetic gene cluster from Streptomyces prunicolor yields novel bicyclic peptide prunipeptin.
Sign Up to like & getrecommendations! Published in 2020 at "Microbiological research"
DOI: 10.1016/j.micres.2020.126669
Abstract: Recently, ω-ester-containing peptides (OEPs) were indicated to be a class of ribosomally synthesized and post-translationally modified peptides. Based on genome mining, new biosynthetic gene cluster of OEPs was found in the genome sequence of actinobacterium… read more here.
Keywords: prunipeptin; peptide; biosynthetic gene; gene cluster ... See more keywords