Targeted Isolation of Hemitheion from Mostuea brunonis, a Proposed Biosynthetic Intermediate of Theionbrunonines.
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DOI: 10.1021/acs.jnatprod.1c00143
Abstract: Hemitheion (1), a new sulfur-containing vobasane-type indole alkaloid, was isolated, together with three known compounds, vobasine (2), gelsedine (3), and gelsemicine (4), from the alkaloid extract of the stems of Mostuea brunonis Didr. (Gelsemiaceae). Compound… read more here.
Keywords: isolation hemitheion; mostuea brunonis; targeted isolation; hemitheion ... See more keywords
A [6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis
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DOI: 10.1038/s41467-021-22395-7
Abstract: Streptoseomycin (STM, 1) is a bacterial macrolactone that has a unique 5/14/10/6/6-pentacyclic ring with an ether bridge. We have previously identified the biosynthetic gene cluster for 1 and characterized StmD as [6 + 4]- and [4 + 2]-bispericyclase that… read more here.
Keywords: cycloaddition adduct; adduct; adduct biosynthetic; intermediate streptoseomycin ... See more keywords