Azide‐ and Alkyne‐Bearing Metabolic Chemical Reporters of Glycosylation Show Structure‐Dependent Feedback Inhibition of the Hexosamine Biosynthetic Pathway
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800280
Abstract: Metabolic chemical reporters (MCRs) of protein glycosylation are analogues of natural monosaccharides that bear reactive groups, like azides and alkynes. When they are added to living cells and organisms, these small molecules are biosynthetically transformed… read more here.
Keywords: metabolic chemical; biosynthetic pathway; hexosamine biosynthetic; chemical reporters ... See more keywords
Evolution of the Biosynthetic Pathway for Cyanogenic Glucosides in Lepidoptera
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DOI: 10.1007/s00239-018-9854-8
Abstract: Cyanogenic glucosides are widespread defence compounds in plants, and they are also found in some arthropods, especially within Lepidoptera. The aliphatic linamarin and lotaustralin are the most common cyanogenic glucosides in Lepidoptera, and they are… read more here.
Keywords: glucosides lepidoptera; evolution biosynthetic; pathway; cyanogenic glucosides ... See more keywords
Investigation of chetomin as a lead compound and its biosynthetic pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Applied microbiology and biotechnology"
DOI: 10.1007/s00253-022-11925-y
Abstract: Chaetomium fungi produce a diversity of bioactive compounds. Chaetomium cochliodes SD-280 possesses 91 secondary metabolite gene clusters and exhibits strong antibacterial activity. One of the active compounds responsible for that activity, chetomin, has a minimum… read more here.
Keywords: biosynthetic pathway; investigation chetomin; chetomin biosynthesis; chetomin ... See more keywords
Structural insight of the 5-(Hydroxyethyl)-methylthiazole kinase ThiM involving vitamin B1 biosynthetic pathway from the Klebsiella pneumoniae.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.08.086
Abstract: Thiamin pyrophosphate (TPP) is an essential co-factor in amino acid and carbohydrate metabolic pathways. The TPP-related vitamin B1 biosynthetic pathway is found in most bacterial, plant and lower eukaryotic processes; however, it is not present… read more here.
Keywords: methylthiazole kinase; hydroxyethyl methylthiazole; vitamin biosynthetic; biosynthetic pathway ... See more keywords
Identification of methionine adenosyltransferase with high diastereoselectivity for biocatalytic synthesis of (S)-S-adenosyl-l-methionine and exploring its relationship with fluorinated biosynthetic pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2021.109881
Abstract: Natural fluorinated products are rare and attract great attention. The de novo fluorometabolites biosynthetic pathway in microbes has been studied. It is revealed that the carbon-fluorine (C-F) bond is formed by an exotic enzyme called… read more here.
Keywords: high diastereoselectivity; methionine; adenosyl methionine; biosynthetic pathway ... See more keywords
Targeted mutagenesis of CYP76AK2 and CYP76AK3 in Salvia miltiorrhiza reveals their roles in tanshinones biosynthetic pathway.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.08.112
Abstract: Salvia miltiorrhiza Bunge, belonging to Lamiaceae family, is one of the most important Chinese medicinal herbs. The dried roots, also called Danshen in Chinese, are usually used in the formula of Chinese traditional medicine due… read more here.
Keywords: tanshinones biosynthetic; miltiorrhiza; cyp76ak3; cyp76ak2 cyp76ak3 ... See more keywords
Identification and analysis of full-length transcripts involved in the biosynthesis of insecticidal lignan (+)-haedoxan A in Phryma leptostachya
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DOI: 10.1016/j.indcrop.2019.111868
Abstract: Abstract Elucidating the biosynthetic pathway of bioactive ingredients will provide an excellent opportunity for their sustainable supply. Phryma leptostachya, a traditional insecticidal plant, is rich in lignans, among which (+)-haedoxan A (HA) is the major… read more here.
Keywords: insecticidal; full length; phryma leptostachya; analysis ... See more keywords
Chromosome-level genome of Himalayan yew provides insights into the origin and evolution of the paclitaxel biosynthetic pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular plant"
DOI: 10.1016/j.molp.2021.04.015
Abstract: Taxus, commonly known as yew, is a well-known gymnosperm with great ornamental and medicinal value. Here by assembling a chromosome-level genome of the Himalayan yew (Taxus wallichiana) with 10.9 Gb in 12 chromosomes, we revealed… read more here.
Keywords: chromosome level; genome himalayan; biosynthetic pathway; genome ... See more keywords
An alternative, zeaxanthin epoxidase-independent abscisic acid biosynthetic pathway in plants.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular plant"
DOI: 10.1016/j.molp.2021.09.008
Abstract: Abscisic acid (ABA) is an important carotenoid-derived phytohormone that plays essential roles in plant response to biotic and abiotic stresses as well as in various physiological and developmental processes. In Arabidopsis, ABA biosynthesis starts with… read more here.
Keywords: apo carotenal; biosynthetic pathway; abscisic acid; cis apo ... See more keywords
In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway.
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DOI: 10.1016/j.phrs.2021.105528
Abstract: Geranylgeranyl diphosphate synthase (GGDPS), an enzyme in the isoprenoid biosynthetic pathway (IBP), produces the isoprenoid (geranylgeranyl pyrophosphate, GGPP) used in protein geranylgeranylation reactions. Our prior studies utilizing triazole bisphosphonate-based GGDPS inhibitors (GGSIs) have revealed that… read more here.
Keywords: combination; protein geranylgeranylation; isoprenoid biosynthetic; therapy ... See more keywords
In vivo deep network tracing reveals phosphofructokinase-mediated coordination of biosynthetic pathway activity in the myocardium.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2021.08.013
Abstract: Glucose metabolism comprises numerous amphibolic metabolites that provide precursors for not only the synthesis of cellular building blocks but also for ATP production. In this study, we tested how phosphofructokinase-1 (PFK1) activity controls the fate… read more here.
Keywords: deep network; biosynthetic pathway; activity; pathway activity ... See more keywords