Construction of ajmalicine and sanguinarine de novo biosynthetic pathways using stable integration sites in yeast
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28040
Abstract: Yeast cell factories have been increasingly employed for producing plant‐derived natural products. Unfortunately, the stability of plant natural product biosynthetic pathway genes, particularly when driven by the same sets of promoters and terminators, remains one… read more here.
Keywords: construction; integration sites; integration; stable integration ... See more keywords
Studies on the biosynthetic pathways of melanin in Auricularia auricula.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of basic microbiology"
DOI: 10.1002/jobm.202100670
Abstract: Melanin is a natural pigment ubiquitously present in living organisms, including bacteria, fungi, plants, and animals. Melanin produced by the edible mushroom Auricularia auricula has a remarkable potential for resource development. Several A. auricula strains… read more here.
Keywords: pathways melanin; biosynthetic pathways; melanin; auricularia auricula ... See more keywords
Characterization of the Polyamine Biosynthetic Pathways and Salt Stress Response in Brachypodium distachyon
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Plant Growth Regulation"
DOI: 10.1007/s00344-017-9761-z
Abstract: To characterize polyamine (PA) biosynthetic pathways in Brachypodium distachyon, we analyzed the gene-expression patterns and PA contents in various organs. Three major PAs—putrescine (Put), spermidine (Spd), and spermine (Spm)—were detected, but thermospermine (T-Spm) was below… read more here.
Keywords: biosynthetic pathways; brachypodium distachyon; polyamine biosynthetic; salt stress ... See more keywords
Perturbations of carotenoid and tetrapyrrole biosynthetic pathways result in differential alterations in chloroplast function and plastid signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.11.092
Abstract: In this study, we used the biosynthetic inhibitors of carotenoid and tetrapyrrole biosynthetic pathways, norflurazon (NF) and oxyfluorfen (OF), as tools to gain insight into mechanisms of photooxidation in rice plants. NF resulted in bleaching… read more here.
Keywords: carotenoid tetrapyrrole; tetrapyrrole biosynthetic; plastid; treated plants ... See more keywords
Combinatorial synthetic pathway fine-tuning and cofactor regeneration for metabolic engineering of Escherichia coli significantly improve production of D-glucaric acid.
Sign Up to like & getrecommendations! Published in 2020 at "New biotechnology"
DOI: 10.1016/j.nbt.2020.03.004
Abstract: D-glucaric acid (GA) has been identified as among promising biotechnological alternatives to oil-based chemicals. GA and its derivatives are widely used in food additives, dietary supplements, drugs, detergents, corrosion inhibitors and biodegradable materials. The increasing… read more here.
Keywords: engineering; fine tuning; metabolic engineering; glucaric acid ... See more keywords
Three Principles of Diversity-Generating Biosynthesis.
Sign Up to like & getrecommendations! Published in 2017 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.7b00330
Abstract: Natural products are significant therapeutic agents and valuable drug leads. This is likely owing to their three-dimensional structural complexity, which enables them to form complex interactions with biological targets. Enzymes from natural product biosynthetic pathways… read more here.
Keywords: biosynthesis; principles diversity; natural products; diversity generating ... See more keywords
Talarolactones A-G, α-Pyrone Dimers with Anti-inflammatory Activities from Talaromyces adpressus, and Their Biosynthetic Pathways.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.2c04352
Abstract: Talarolactones A-G (1-7), seven novel α-pyrone adducts with unprecedented scaffolds, together with two pairs of α-pyrone monomers [(±)-8 and (±)-9)] were isolated from Talaromyces adpressus. Compounds 1-7 are highly modified α-pyrone dimers with a 4,7,7,8-tetrasubstitued… read more here.
Keywords: pyrone dimers; pyrone; talaromyces adpressus; talarolactones pyrone ... See more keywords
Spatially organizing biochemistry: choosing a strategy to translate synthetic biology to the factory
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-26399-0
Abstract: Natural biochemical systems are ubiquitously organized both in space and time. Engineering the spatial organization of biochemistry has emerged as a key theme of synthetic biology, with numerous technologies promising improved biosynthetic pathway performance. One… read more here.
Keywords: biochemistry; spatially organizing; synthetic biology; biology ... See more keywords
Unveiling the presence of biosynthetic pathways for bioactive compounds in the Thalassiosira rotula transcriptome
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-46276-8
Abstract: Diatoms are phytoplankton eukaryotic microalgae that are widely distributed in the world’s oceans and are responsible for 20–25% of total carbon fixation on the planet. Using transcriptome sequencing here we show for the first time… read more here.
Keywords: thalassiosira rotula; pathways bioactive; presence biosynthetic; unveiling presence ... See more keywords
Elucidating the biosynthetic pathways of volatile organic compounds in Mycobacterium tuberculosis through a computational approach.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c6mb00796a
Abstract: Microbial volatile organic compounds (VOCs) have gained prominence in the recent past for their potential use as disease markers. The discovery of microbial VOCs has benefited 'difficult to detect' diseases such as tuberculosis (TB). Few… read more here.
Keywords: organic compounds; volatile organic; tuberculosis; biosynthetic pathways ... See more keywords
Responses of Synechocystis sp. PCC 6803 to heterologous biosynthetic pathways
Sign Up to like & getrecommendations! Published in 2017 at "Microbial Cell Factories"
DOI: 10.1186/s12934-017-0757-y
Abstract: BackgroundThere are an increasing number of studies regarding genetic manipulation of cyanobacteria to produce commercially interesting compounds. The majority of these works study the expression and optimization of a selected heterologous pathway, largely ignoring the… read more here.
Keywords: heterologous biosynthetic; pcc 6803; synechocystis pcc; 6803 heterologous ... See more keywords