Technical Advances to Accelerate Modular Type I Polyketide Synthase Engineering towards a Retro-biosynthetic Platform
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioprocess Engineering"
DOI: 10.1007/s12257-019-0083-9
Abstract: Modular type I polyketide synthases (PKSs) are multifunctional proteins that are comprised of individual domains organized into modules. These modules act together to assemble complex polyketides from acyl-CoA substrates in a linear fashion. This assembly-line… read more here.
Keywords: type polyketide; engineering; biosynthetic platform; retro biosynthetic ... See more keywords
An E. coli-Based Biosynthetic Platform Expands the Structural Diversity of Natural Benzoxazoles.
Sign Up to like & getrecommendations! Published in 2021 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.1c00228
Abstract: Benzoxazoles are frequently found in synthetic pharmaceuticals and medicinally active natural products. To facilitate benzoxazole-based drug development, an eco-friendly and rapid platform for benzoxazole production is required. In this study, we have completed the biosynthesis… read more here.
Keywords: coli based; biosynthesis; benzoxazoles coli; biosynthetic platform ... See more keywords