Control of biotin biosynthesis in mycobacteria by a pyruvate carboxylase dependent metabolic signal
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DOI: 10.1111/mmi.13865
Abstract: Biotin is an essential cofactor utilized by all domains of life, but only synthesized by bacteria, fungi and plants, making biotin biosynthesis a target for antimicrobial development. To understand biotin biosynthesis in mycobacteria, we executed… read more here.
Keywords: biosynthesis mycobacteria; biotin; biotin biosynthesis; pyruvate carboxylase ... See more keywords
Crystal structure and acetylation of BioQ suggests a novel regulatory switch for biotin biosynthesis in Mycobacterium smegmatis
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Microbiology"
DOI: 10.1111/mmi.14066
Abstract: Biotin (vitamin B7), a sulfur‐containing fatty acid derivative, is a nutritional virulence factor in certain mycobacterial species. Tight regulation of biotin biosynthesis is important because production of biotin is an energetically expensive process requiring 15–20… read more here.
Keywords: acetylation; biotin; bioq; biotin biosynthesis ... See more keywords
XRE-Type Regulator BioX Acts as a Negative Transcriptional Factor of Biotin Metabolism in Riemerella anatipestifer
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DOI: 10.1128/jb.00181-21
Abstract: Riemerella anatipestifer is a causative agent of diseases in ducks, geese, turkeys, and various other domestic and wild birds. Our study reveals that biotin synthesis of R. anatipestifer is regulated by the BioX through binding… read more here.
Keywords: biotin; biotin biosynthesis; biox; riemerella anatipestifer ... See more keywords