Strategies for mitigating risk posed by biotin interference on clinical immunoassays.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical biochemistry"
DOI: 10.1016/j.clinbiochem.2018.12.007
Abstract: Recently, biotin use as an oral supplement has increased significantly among the general population. Biotin is a water soluble B-vitamin and is marketed to improve the cosmetic appearance of hair, skin, and nails. In addition,… read more here.
Keywords: strategies mitigating; mitigating risk; interference; biotin interference ... See more keywords
Serum biotin interference: A troublemaker in hormone immunoassays.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical biochemistry"
DOI: 10.1016/j.clinbiochem.2021.10.011
Abstract: OBJECTIVES Biotin therapy can affect the results of many immunoassay procedures. The present study investigates biotin's interference on 25-hydroxy vitamin D(25-OHD), parathyroidhormone(PTH) and thyroid-stimulating hormone(TSH) tests using four different assay systems and biotin neutralization. DESIGN… read more here.
Keywords: roche assay; biotin; biotin interference; neutralization ... See more keywords
Comparison of Biotin Interference in Second- and Third-Generation Roche Free Thyroxine Immunoassays
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Laboratory Medicine"
DOI: 10.3343/alm.2020.40.3.274
Abstract: Dear Editor, Immunoassays (IAs) based on streptavidin-biotin binding are widely used in clinical laboratory testing owing to the high affinity and stable interaction between streptavidin and biotin (vitamin B7) and the development of various biotinylation… read more here.
Keywords: biotin; interference; roche diagnostics; streptavidin biotin ... See more keywords
Development and Evaluation of an Anti-Biotin Interference Method in Biotin-Streptavidin Immunoassays
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostics"
DOI: 10.3390/diagnostics12071729
Abstract: The strong non-covalent interaction between biotin and streptavidin places streptavidin-based assays, used by many laboratories, at an increased risk of interference by biotin. At present, a few manufacturers have developed fully automated anti-biotin interference methods,… read more here.
Keywords: biotin streptavidin; biotin interference; interference; biotin ... See more keywords
Biotin Interference in Susceptible CanAg Ca242 Immunoassays and Elimination Method.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical laboratory"
DOI: 10.7754/clin.lab.2019.191141
Abstract: BACKGROUND High-dose biotin therapy is beneficial in progressive multiple sclerosis (MS). Biotin, as dietary supplement or therapy, may lead to analytical interference in biotin-streptavidin immunoassay. METHODS Seven concentration gradients of biotin solutions were spiked to… read more here.
Keywords: biotin interference; biotin; streptavidin; canag ca242 ... See more keywords