Structural Study of Potent Triazole-Based Inhibitors of Staphylococcus aureus Biotin Protein Ligase.
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DOI: 10.1021/acsmedchemlett.2c00505
Abstract: The rise of multidrug-resistant bacteria, such as Staphylococcus aureus, has highlighted global urgency for new classes of antibiotics. Biotin protein ligase (BPL), a critical metabolic regulatory enzyme, is an important target that shows significant promise… read more here.
Keywords: staphylococcus aureus; protein ligase; triazole based; structural study ... See more keywords
Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase
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DOI: 10.3390/antibiotics9040165
Abstract: Biotin protein ligase (BPL) inhibitors are a novel class of antibacterial that target clinically important methicillin-resistant Staphylococcus aureus (S. aureus). In S. aureus, BPL is a bifunctional protein responsible for enzymatic biotinylation of two biotin-dependent… read more here.
Keywords: staphylococcus aureus; biotin; bpl; resistance ... See more keywords