Studying the Biotransformation of Phosphorothioate-Containing Oligonucleotide Drugs by LC-MS.
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DOI: 10.1007/978-1-4939-9670-4_18
Abstract: Across the pharmaceutical industry, there is increasing interest and need to investigate the biotransformation of oligonucleotide drugs. The method of choice is high-resolution mass spectrometry due to its unmet sensitivity and specificity.Here, we describe a… read more here.
Keywords: studying biotransformation; containing oligonucleotide; oligonucleotide drugs; phosphorothioate containing ... See more keywords