LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "bip" as a keyword



Photo by jontyson from unsplash

TT-BIP: using correct-by-design BIP approach for modelling real-time system with time-triggered paradigm

Sign Up to like & get
recommendations! Published in 2018 at "Innovations in Systems and Software Engineering"

DOI: 10.1007/s11334-018-0312-y

Abstract: In order to combine advantages of real-time operating systems implementing the time-triggered (TT) execution model and model-based design frameworks, we aim at proposing a correct-by-design methodology that derives correct TT implementations from high-level models. This… read more here.

Keywords: methodology; real time; model; bip ... See more keywords
Photo from wikipedia

Evaluating the Impact of Nonrandom Mating: Psychiatric Outcomes Among the Offspring of Pairs Diagnosed With Schizophrenia and Bipolar Disorder

Sign Up to like & get
recommendations! Published in 2020 at "Biological Psychiatry"

DOI: 10.1016/j.biopsych.2019.06.025

Abstract: BACKGROUND Nonrandom mating has been shown for psychiatric diagnoses, with hypothesized-but not quantified-implications for offspring liability. This national cohort study enumerated the incidence of major psychiatric disorders among the offspring of parent pairs affected with… read more here.

Keywords: scz; among offspring; disorder; bipolar disorder ... See more keywords
Photo from wikipedia

HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum.

Sign Up to like & get
recommendations! Published in 2017 at "Gene"

DOI: 10.1016/j.gene.2017.03.005

Abstract: The HSPA5 gene encodes the binding immunoglobulin protein (BiP), an Hsp70 family chaperone localized in the ER lumen. As a highly conserved molecular chaperone, BiP assists in a wide range of folding processes via its… read more here.

Keywords: protein; hspa5 gene; chaperone bip; bip ... See more keywords
Photo from wikipedia

The ball in play demands of international rugby union.

Sign Up to like & get
recommendations! Published in 2018 at "Journal of science and medicine in sport"

DOI: 10.1016/j.jsams.2018.02.015

Abstract: OBJECTIVES Rugby union is a high intensity intermittent sport, typically analysed via set time periods or rolling average methods. This study reports the demands of international rugby union via global positioning system (GPS) metrics expressed… read more here.

Keywords: rugby union; play; international rugby; demands international ... See more keywords
Photo from wikipedia

Target Profiling of an Iridium(III)-Based Immunogenic Cell Death Inducer Unveils the Engagement of Unfolded Protein Response Regulator BiP.

Sign Up to like & get
recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.2c02435

Abstract: Clinical chemotherapeutic drugs have occasionally been observed to induce antitumor immune responses beyond the direct cytotoxicity. Such effects are coined as immunogenic cell death (ICD), representing a "second hit" from the host immune system to… read more here.

Keywords: cell death; unfolded protein; immunogenic cell; icd ... See more keywords
Photo from wikipedia

Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD

Sign Up to like & get
recommendations! Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-22596-0

Abstract: To adapt to fluctuating protein folding loads in the endoplasmic reticulum (ER), the Hsp70 chaperone BiP is reversibly modified with adenosine monophosphate (AMP) by the ER-resident Fic-enzyme FICD/HYPE. The structural basis for BiP binding and… read more here.

Keywords: tpr motifs; chaperone bip; motifs ficd; ampylation ... See more keywords
Photo from wikipedia

Mechanism of BIP-4 mediated inhibition of InsP3Kinase-A

Sign Up to like & get
recommendations! Published in 2021 at "Bioscience Reports"

DOI: 10.1042/bsr20211259

Abstract: Overexpression of the neuronal InsP3kinase-A increases malignancy of different tumor types. Since InsP3kinase-A highly selectively binds Ins(1,4,5)P3, small molecules competing with Ins(1,4,5)P3 provide a promising approach for the therapeutic targeting of InsP3kinase-A. Based on this… read more here.

Keywords: bip mediated; bip; mechanism bip; insp3kinase ... See more keywords
Photo by boxedwater from unsplash

Bip-Yorkie interaction determines oncogenic and tumor-suppressive roles of Ire1/Xbp1s activation

Sign Up to like & get
recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2202133119

Abstract: Significance Unfolded protein response (UPR) is thought to coordinate cell growth and proliferation by governing endoplasmic reticulum (ER) proteostasis; however, the mechanisms underlying this fundamental adaptation process remain poorly defined. Here, by using Drosophila, mammalian… read more here.

Keywords: yorkie interaction; ire1 xbp1s; bip yorkie; bip ... See more keywords
Photo from wikipedia

The influence of ball in/out of play and possession in elite soccer: Towards a more valid measure of physical intensity during competitive match-play.

Sign Up to like & get
recommendations! Published in 2023 at "European journal of sport science"

DOI: 10.1080/17461391.2023.2203120

Abstract: The physical demands of soccer match-play have typically been assessed using a low-resolution whole match approach ignoring whether the ball is in or out of play (BIP/BOP) and during these periods which team has possession.… read more here.

Keywords: physical intensity; possession; match; play ... See more keywords
Photo by sammiechaffin from unsplash

T173. POLYGENETIC RISK SCORES FOR MAJOR PSYCHIATRIC DISORDERS AMONG SCHIZOPHRENIA PATIENTS, THEIR FIRST-DEGREE RELATIVES AND HEALTHY SUBJECTS

Sign Up to like & get
recommendations! Published in 2020 at "Schizophrenia Bulletin"

DOI: 10.1093/schbul/sbaa029.733

Abstract: Abstract Background The genetic etiology of schizophrenia (SCZ) overlaps with that of other major psychiatric disorders in samples of European ancestry. On the other hand, these major psychiatric disorders are distinct diagnoses that have disorder-specific… read more here.

Keywords: scz; risk; hcs; psychiatric disorders ... See more keywords
Photo from wikipedia

AMPylation and Endoplasmic Reticulum Protein Folding Homeostasis.

Sign Up to like & get
recommendations! Published in 2022 at "Cold Spring Harbor perspectives in biology"

DOI: 10.1101/cshperspect.a041265

Abstract: The endoplasmic reticulum (ER)-localized Hsp70 chaperone, BiP, undergoes a rapid, reversible and inactivating post-translational modification. This covalent modification complements the slower, conventional unfolded protein response (UPR) in matching the supply of active Hsp70 chaperone to… read more here.

Keywords: endoplasmic reticulum; protein folding; bip; ampylation ... See more keywords