A Biparatopic Antibody That Modulates MET Trafficking Exhibits Enhanced Efficacy Compared with Parental Antibodies in MET-Driven Tumor Models
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DOI: 10.1158/1078-0432.ccr-19-2428
Abstract: Purpose: Recent clinical data demonstrate that tumors harboring MET genetic alterations (exon 14 skip mutations and/or gene amplification) respond to small-molecule tyrosine kinase inhibitors, validating MET as a therapeutic target. Although antibody-mediated blockade of the… read more here.
Keywords: enhanced efficacy; tumor models; biparatopic antibody; parental antibodies ... See more keywords