Development of In Vivo Predictive pH-Gradient Biphasic Dissolution Test for Weakly Basic Drugs: Optimization by Orthogonal Design
Sign Up to like & getrecommendations! Published in 2021 at "Dissolution Technologies"
DOI: 10.14227/dt280321p24
Abstract: The aim of this study was to develop a method for set up and optimization of a pH-gradient biphasic dissolution model by orthogonal test design in light of the correlation with published in vivo data… read more here.
Keywords: biphasic dissolution; dissolution test; dissolution; test ... See more keywords
A Rational Design of a Biphasic Dissolution Setup—Modelling of Biorelevant Kinetics for a Ritonavir Hot-Melt Extruded Amorphous Solid Dispersion
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DOI: 10.3390/pharmaceutics12030237
Abstract: Biphasic dissolution systems achieved good predictability for the in vivo performance of several formulations of poorly water-soluble drugs by characterizing dissolution, precipitation, re-dissolution, and absorption. To achieve a high degree of predictive performance, acceptor media,… read more here.
Keywords: solid dispersion; amorphous solid; hot melt; biphasic dissolution ... See more keywords
In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14081657
Abstract: In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as a species for early efficacy… read more here.
Keywords: vitro vivo; vivo; dissolution; biphasic dissolution ... See more keywords