Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy319
Abstract: &NA; Birdshot Uveitis (Birdshot) is a rare eye condition that affects HLA‐A29‐positive individuals and could be considered a prototypic member of the recently proposed ‘MHC‐I (major histocompatibility complex class I)‐opathy’ family. Genetic studies have pinpointed… read more here.
Keywords: erap1 erap2; haplotype; erap1; birdshot uveitis ... See more keywords
ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.634441
Abstract: Birdshot Uveitis (BU) is a blinding inflammatory eye condition that only affects HLA-A29-positive individuals. Genetic association studies linked ERAP2 with BU, an aminopeptidase which trims peptides before their presentation by HLA class I at the… read more here.
Keywords: hla a29; effects erap2; birdshot uveitis; hla ... See more keywords