The SMAC mimetic birinapant attenuates lipopolysaccharide-induced liver injury by inhibiting the tumor necrosis factor receptor-associated factor 3 degradation in Kupffer cells.
Sign Up to like & getrecommendations! Published in 2017 at "Immunology letters"
DOI: 10.1016/j.imlet.2017.02.016
Abstract: It was demonstrated that second mitochondria-derived activator of caspases (SMAC) mimetic inhibites tumor necrosis factor receptor-associated factor 3 (TRAF3) degradation and the mitogen-activated protein kinase (MAPK) signaling pathway activation induced by lipopolysaccharide (LPS) in vitro.… read more here.
Keywords: birinapant; smac mimetic; liver injury; induced liver ... See more keywords
Birinapant improves imiquimod-induced psoriasis in BALB/c mice
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DOI: 10.1080/08923973.2025.2470345
Abstract: Abstract Objectives This study investigates the effects of birinapant, a novel compound, on psoriasis-like symptoms induced by imiquimod in Balb/c mice. Material and methods Male Balb/c mice were treated with imiquimod (IMQ) to induce psoriasis-like… read more here.
Keywords: induced psoriasis; balb mice; psoriasis; birinapant ... See more keywords
Birinapant Reshapes the Tumor Immunopeptidome and Enhances Antigen Presentation
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DOI: 10.3390/ijms25073660
Abstract: Birinapant, an antagonist of the inhibitor of apoptosis proteins, upregulates MHCs in tumor cells and displays a better tumoricidal effect when used in combination with immune checkpoint inhibitors, indicating that Birinapant may affect the antigen… read more here.
Keywords: tumor immunopeptidome; antigen presentation; tumor; presentation ... See more keywords
SMAC mimetic birinapant inhibits hepatocellular carcinoma growth by activating the cIAP1/TRAF3 signaling pathway
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DOI: 10.3892/mmr.2020.10908
Abstract: The present study investigated the effects and molecular mechanism of the second mitochondria-derived activator of caspase (SMAC) mimetic birinapant on the proliferation and apoptotic rate of liver cancer cells. Western blotting and reverse transcription-quantitative PCR… read more here.
Keywords: birinapant; ciap1 traf3; liver cancer; cancer cells ... See more keywords