Bis-γ-carbolines as new potential multitarget agents for Alzheimer’s disease
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DOI: 10.1515/pac-2019-1206
Abstract: Abstract A new series of homobivalent Dimebon analogs, bis-γ-carbolines with alkylene, phenylenedialkylene, and triazole-containing spacers, was synthesized. Doubling the γ-carboline pharmacophore increased inhibitory potency against acetylcholinesterase (AChE) compared with Dimebon, while keeping Dimebon’s anti-butyrylcholinesterase activity;… read more here.
Keywords: agents alzheimer; alzheimer disease; multitarget agents; bis carbolines ... See more keywords