Design, synthesis, and molecular docking study of novel quinoline‐based bis‐chalcones as potential antitumor agents
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DOI: 10.1002/ardp.202100094
Abstract: A novel series of quinoline‐based symmetrical and unsymmetrical bis‐chalcones was synthesized via a Claisen–Schmidt condensation reaction between 3‐formyl‐quinoline/quinolone derivatives with acetone or arylidene acetones, respectively, by using KOH/MeOH/H2O as a reaction medium. Twelve of the… read more here.
Keywords: design synthesis; bis chalcones; quinoline; bis ... See more keywords
Bis-Chalcones: Recent Reports of Their Diverse Applications in Biological and Material Sciences
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DOI: 10.1021/acsomega.4c04635
Abstract: Originating from the basic chalcone structure, bis-chalcones are characterized by their dual α,β-unsaturated carbonyl systems and carry a range of biological activities that include antimicrobial, antiviral, antiparasitic, antioxidant, antiproliferative, and chemical reactivities that warrant a… read more here.
Keywords: chalcones recent; reports diverse; bis chalcones; applications biological ... See more keywords
Antioxidant, Antimicrobial, Cytotoxicity, and Larvicidal Activities of Selected Synthetic Bis-Chalcones
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DOI: 10.3390/molecules27238209
Abstract: Plants are known to have numerous phytochemicals and other secondary metabolites with numerous pharmacological and biological properties. Among the various compounds, polyphenols, flavonoids, anthocyanins, alkaloids, and terpenoids are the predominant ones that have been explored… read more here.
Keywords: synthetic bis; cytotoxicity larvicidal; antioxidant antimicrobial; bis chalcones ... See more keywords
Synthesis of bis-Chalcones Based on Green Chemistry Strategies and Their Cytotoxicity Toward Human MeWo and A375 Melanoma Cell Lines
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DOI: 10.3390/molecules29215171
Abstract: Chalcone is an aromatic ketone that forms the central core of many important biological compounds. Chalcone derivatives show various biological activities, especially anti-inflammatory, antibacterial, antioxidant, and anticancer activities, and also inhibit melanoma cell growth. In… read more here.
Keywords: chemistry; bis chalcones; bis; melanoma cell ... See more keywords