Sustainable and scalable synthesis of polysubstituted bis-1,2,4-triazoles, bis-2-iminothiazolines and bis-thiobarbiturates using bis-N,N-disubstituted thioureas as versatile substrate
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DOI: 10.1098/rsos.181963
Abstract: An expedient and tandem regioselective one-pot protocol for the sono-synthesis of bis-[1,2,4]-triazol-3-yl amines and bis-2-iminothiazolines from corresponding bis-1,3-disubstituted thioureas has been developed. The products' regioselectivity correlate well with the pKas of the parent amines, in… read more here.
Keywords: bis disubstituted; sustainable scalable; disubstituted thioureas; bis iminothiazolines ... See more keywords
Synthesis and Antimicrobial Evaluation of Bis-3,5-disubstituted Isoxazoles Based Chalcones
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DOI: 10.1134/s1070363218090232
Abstract: A series of bis-isoxazoles blended chalcones 7a–7j are synthesized in high yields. The combination of three pharmacologically active moieties in a single scaffold results in the synergistic effect in their bioactivity. All the newly synthesized… read more here.
Keywords: disubstituted isoxazoles; evaluation bis; antimicrobial evaluation; bis disubstituted ... See more keywords