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Published in 2019 at "Planta medica"
DOI: 10.1055/a-1028-7786
Abstract: Three new (1: -3: ) and 2 known (4: -5: ) bis-indole alkaloids were identified from the bark of Flindersia pimenteliana (Rutaceae). The structures of 1: -3: were elucidated on the basis of their (+)-HRESESIMS…
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Keywords:
bis indole;
bark flindersia;
flindersia pimenteliana;
indole alkaloids ... See more keywords
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Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2017-03049
Abstract: Treatment of C2C12 muscle cells with metformin or the NR4A1 ligand 1,1-bis(3'-indolyl)-1-(p-hydroxyphenyl)methane (DIM-C-pPhOH) induced NR4A1 and Glut4 messenger RNA and protein expression. Similar results were observed with buttressed (3- or 3,5-substituted) analogs of DIM-C-pPhOH, including…
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Keywords:
c2c12 cells;
nr4a1 ligands;
uptake c2c12;
bis indole ... See more keywords
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Published in 2020 at "Endocrinology"
DOI: 10.1210/endocr/bqaa027
Abstract: Endometriosis is an inflammatory disease that primarily affects women during their reproductive years and since current hormonal therapies are of concern new hormone-independent treatment regimens are needed. The orphan nuclear receptor 4A1 (NR4A1, Nur77) is…
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Keywords:
nr4a1 nur77;
bis indole;
4a1 nr4a1;
receptor 4a1 ... See more keywords
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Published in 2022 at "Molecules"
DOI: 10.3390/molecules27185781
Abstract: Isatin and its derivatives are important heterocycles found in nature and present in numerous bioactive compounds which possess various biological activities. Moreover, it is an essential building block in organic synthesis. The discovery of novel…
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Keywords:
isatin bis;
bis;
bis indole;
indole bis ... See more keywords
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Published in 2022 at "Molecules"
DOI: 10.3390/molecules28010251
Abstract: This work deals with the study of the synthesis of new bis-indole analogues with a phenyl linker derived from indole phytoalexins. Synthesis of target bis-indole thiourea linked by a phenyl linker was achieved by the…
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Keywords:
indole thiourea;
compound;
bis;
bis indole ... See more keywords