Synthesis Of Biologically Active Bis(Indolyl)Methane Derivatives by Bisindole Alkylation of Tetrahydroisoquinolines with Visible‐Light Induced Ring‐Opening Fragmentation.
Sign Up to like & getrecommendations! Published in 2017 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.201600415
Abstract: A visible-light photoredox catalyzed ring-opening functionalization of tetrahydroisoquinolines with bisindole alkylation has been developed, which expedites a new vista for the synthesis of bis(indolyl)methane derivatives. The transformation comprises a series of cascade reactions, photoredox catalysis,… read more here.
Keywords: alkylation; indolyl methane; methane derivatives; bis indolyl ... See more keywords
Mechanosynthesis of Triazolyl‐bis(indolyl)methane Pharmacophores via Gold Catalysis: A Prelude to Their Molecular Electronic Properties and Biological Potency
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200529
Abstract: Chemical structures possessing both 1,2,3‐triazole and bis(indolyl)methane fragments gained considerable interest in drug synthesis owing to their established biological efficacies. However, 1,2,3‐triazoles linked at the bridging position of bis(indolyl)methane is a logical and unexplored design… read more here.
Keywords: triazolyl bis; indolyl methane; bis indolyl;
Chemoselective synthesis of bis(indolyl)methanes using sulfonic acid-functionalized chitosan
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Papers"
DOI: 10.1007/s11696-019-00846-2
Abstract: Herein, we describe the electrophilic substitution reaction of indole with aldehydes and ketone using sulphonic acid functional group containing chitosan for the synthesis of bis(indolyl)methanes. The reaction is chemoselective affording a product from aldehydes and… read more here.
Keywords: indolyl methanes; synthesis bis; bis indolyl;
Condition-controlled selective synthesis of hydroxyl(indolyl)- and bis(indolyl)barbiturates
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-017-1075-3
Abstract: By combining the structural features of indole and barbituric acid, new hybrid molecules were designed and synthesized. Hydroxy(indolyl)barbiturates and bis(indolyl)barbiturates were selectively prepared via the reaction of indoles with alloxan derivatives in various conditions.Graphical Abstract read more here.
Keywords: bis indolyl; indolyl barbiturates; selective synthesis; controlled selective ... See more keywords
Tris(hydroxymethyl)methane ammonium hydrogensulphate as a nano ionic liquid and its catalytic activity in the synthesis of bis(indolyl)methanes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2016.10.136
Abstract: Abstract In this study, tris(hydroxymethyl)methane ammonium hydrogensulphate [(THA)(HSO4)] was synthesized as the first nanoaliphatic ammonium-based ionic liquid via a simple chemical route in water. The [(THA)(HSO4)] ionic liquid was characterized by various techniques such as… read more here.
Keywords: ionic liquid; bis indolyl; tris hydroxymethyl; methane ... See more keywords
Synthesis, characterization, UV–Vis absorption and cholinesterase inhibition properties of bis-indolyl imine ligand systems
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.128308
Abstract: Abstract A number of bis-indolyl imine helical structures has successfully been synthesized employing Schiff base reaction conditions starting from 4,6-dimethoxy-2,3-diphenylindole with different o-phenyl diamines as π-spacer bridged. The structures of targeted compounds were identified by… read more here.
Keywords: bis indolyl; vis absorption; spectroscopy; properties bis ... See more keywords
Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.02.026
Abstract: Abstract Flow chemistry enables the preparation of bis(indolyl)methanes from various indoles and structurally divergent aldehydes using Sc(OTf) 3 catalysis. The reaction is regioselective for C-3 functionalization of the indoles, occurring over short reaction times allowing… read more here.
Keywords: indolyl methanes; flow chemistry; chemistry; bis indolyl ... See more keywords
Catalytic Enantioselective Synthesis of 2,3'-Bis(indolyl)methanes Bearing All-Carbon Quaternary Stereocenters via 2-Indole Imine Methides.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.2c04109
Abstract: An organocatalytic enantioselective formal hydroarylation of 2-vinyl indoles for the preparation of enantioenriched 2,3'-bis(indolyl)methanes bearing an all-carbon quaternary stereocenter is described. This reaction features mild conditions, low catalyst loading, excellent efficiency and enantioselectivity. The obtained… read more here.
Keywords: bearing carbon; indolyl methanes; carbon quaternary; bis indolyl ... See more keywords
Catalyst-Controlled Diastereoselective Synthesis of Bridged [3.3.1] Bis(Indolyl)-Oxanes and Oxepanes via Desymmetrization of Bis(Indolyl)-Cyclohexadienones.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00834
Abstract: A catalyst-controlled divergent synthesis of bridged [3.3.1] bis(indolyl)-oxanes and cis-[6.7] fused bis(indolyl) oxepanes via diastereoselective desymmetrization of bis(indolyl)-cyclohexadienones is presented for the first time. The reaction is highly atom- and step-economic, furnishing sp3-rich functionalized bis(indolyl)… read more here.
Keywords: catalyst controlled; synthesis bridged; bis; bis indolyl ... See more keywords
Gold(I)-Catalyzed and Ligand-Controlled Regioselective Cascade Cycloisomerizations of Bis(indolyl)-1,3-diynes and a Mechanistic Explanation.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02778
Abstract: A regioselective synthetic method for the preparation of indole-fused seven-membered rings and bis(indole) connected to five-membered heterocyclic units from gold(I)-catalyzed cascade cycloisomerization of bis(indolyl)-1,3-diynes is described. This divergence in product selectivity was induced by introducing… read more here.
Keywords: indolyl diynes; bis indolyl; ligand controlled; catalyzed ligand ... See more keywords
Effective Synthesis and Biological Evaluation of Natural and Designed Bis(indolyl)methanes via Taurine-Catalyzed Green Approach
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c07258
Abstract: An ecofriendly, inexpensive, and efficient route for synthesizing 3,3′-bis(indolyl)methanes (BIMs) and their derivatives was carried out by an electrophilic substitution reaction of indole with structurally divergent aldehydes and ketones using taurine and water as a… read more here.
Keywords: effective synthesis; synthesis biological; indolyl methanes; biological evaluation ... See more keywords