Synthesis Of Biologically Active Bis(Indolyl)Methane Derivatives by Bisindole Alkylation of Tetrahydroisoquinolines with Visible‐Light Induced Ring‐Opening Fragmentation.
Sign Up to like & getrecommendations! Published in 2017 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.201600415
Abstract: A visible-light photoredox catalyzed ring-opening functionalization of tetrahydroisoquinolines with bisindole alkylation has been developed, which expedites a new vista for the synthesis of bis(indolyl)methane derivatives. The transformation comprises a series of cascade reactions, photoredox catalysis,… read more here.
Keywords: alkylation; indolyl methane; methane derivatives; bis indolyl ... See more keywords
TEMPO‐Mediated Cross‐Dehydrogenative Coupling for the Synthesis of Bis(indolyl)methanes
Sign Up to like & getrecommendations! Published in 2024 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202400484
Abstract: A TEMPO‐oxidized method has been developed for the synthesis of bis(indolyl)‐methane derivatives by the cross‐dehydrogenative coupling between C(sp3)–H of para‐cresol derivatives and C(sp2)‐H of indoles in moderate yields under aqueous conditions. This approach has significant… read more here.
Keywords: cross dehydrogenative; dehydrogenative coupling; synthesis bis; bis indolyl ... See more keywords
Mechanosynthesis of Triazolyl‐bis(indolyl)methane Pharmacophores via Gold Catalysis: A Prelude to Their Molecular Electronic Properties and Biological Potency
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DOI: 10.1002/cmdc.202200529
Abstract: Chemical structures possessing both 1,2,3‐triazole and bis(indolyl)methane fragments gained considerable interest in drug synthesis owing to their established biological efficacies. However, 1,2,3‐triazoles linked at the bridging position of bis(indolyl)methane is a logical and unexplored design… read more here.
Keywords: triazolyl bis; indolyl methane; bis indolyl;
Collective Synthesis of Indole‐Derived Natural Products via Halogen Bond Donor Catalysis: Efficient Access to Arundine, Turbomycin B, and Arsindoline A Through 3,3′‐Bis(Indolyl)methane Assembly
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.70100
Abstract: Halogen bonding, a directional and tunable non‐covalent interaction, has recently gained attention as a sustainable alternative to hydrogen bonding in organic synthesis. Herein, we introduce a novel and sustainable halogen bond‐driven strategy for the synthesis… read more here.
Keywords: indolyl methane; halogen bond; halogen; synthesis ... See more keywords
Chemoselective synthesis of bis(indolyl)methanes using sulfonic acid-functionalized chitosan
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DOI: 10.1007/s11696-019-00846-2
Abstract: Herein, we describe the electrophilic substitution reaction of indole with aldehydes and ketone using sulphonic acid functional group containing chitosan for the synthesis of bis(indolyl)methanes. The reaction is chemoselective affording a product from aldehydes and… read more here.
Keywords: indolyl methanes; synthesis bis; bis indolyl;
Condition-controlled selective synthesis of hydroxyl(indolyl)- and bis(indolyl)barbiturates
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-017-1075-3
Abstract: By combining the structural features of indole and barbituric acid, new hybrid molecules were designed and synthesized. Hydroxy(indolyl)barbiturates and bis(indolyl)barbiturates were selectively prepared via the reaction of indoles with alloxan derivatives in various conditions.Graphical Abstract read more here.
Keywords: bis indolyl; indolyl barbiturates; selective synthesis; controlled selective ... See more keywords
Tris(hydroxymethyl)methane ammonium hydrogensulphate as a nano ionic liquid and its catalytic activity in the synthesis of bis(indolyl)methanes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2016.10.136
Abstract: Abstract In this study, tris(hydroxymethyl)methane ammonium hydrogensulphate [(THA)(HSO4)] was synthesized as the first nanoaliphatic ammonium-based ionic liquid via a simple chemical route in water. The [(THA)(HSO4)] ionic liquid was characterized by various techniques such as… read more here.
Keywords: ionic liquid; bis indolyl; tris hydroxymethyl; methane ... See more keywords
Synthesis, characterization, UV–Vis absorption and cholinesterase inhibition properties of bis-indolyl imine ligand systems
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DOI: 10.1016/j.molstruc.2020.128308
Abstract: Abstract A number of bis-indolyl imine helical structures has successfully been synthesized employing Schiff base reaction conditions starting from 4,6-dimethoxy-2,3-diphenylindole with different o-phenyl diamines as π-spacer bridged. The structures of targeted compounds were identified by… read more here.
Keywords: bis indolyl; vis absorption; spectroscopy; properties bis ... See more keywords
Utilization of flow chemistry in catalysis: New avenues for the selective synthesis of Bis(indolyl)methanes
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DOI: 10.1016/j.tet.2017.02.026
Abstract: Abstract Flow chemistry enables the preparation of bis(indolyl)methanes from various indoles and structurally divergent aldehydes using Sc(OTf) 3 catalysis. The reaction is regioselective for C-3 functionalization of the indoles, occurring over short reaction times allowing… read more here.
Keywords: indolyl methanes; flow chemistry; chemistry; bis indolyl ... See more keywords
Catalytic Enantioselective Synthesis of 2,3'-Bis(indolyl)methanes Bearing All-Carbon Quaternary Stereocenters via 2-Indole Imine Methides.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.2c04109
Abstract: An organocatalytic enantioselective formal hydroarylation of 2-vinyl indoles for the preparation of enantioenriched 2,3'-bis(indolyl)methanes bearing an all-carbon quaternary stereocenter is described. This reaction features mild conditions, low catalyst loading, excellent efficiency and enantioselectivity. The obtained… read more here.
Keywords: bearing carbon; indolyl methanes; carbon quaternary; bis indolyl ... See more keywords
Catalyst-Controlled Diastereoselective Synthesis of Bridged [3.3.1] Bis(Indolyl)-Oxanes and Oxepanes via Desymmetrization of Bis(Indolyl)-Cyclohexadienones.
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DOI: 10.1021/acs.orglett.3c00834
Abstract: A catalyst-controlled divergent synthesis of bridged [3.3.1] bis(indolyl)-oxanes and cis-[6.7] fused bis(indolyl) oxepanes via diastereoselective desymmetrization of bis(indolyl)-cyclohexadienones is presented for the first time. The reaction is highly atom- and step-economic, furnishing sp3-rich functionalized bis(indolyl)… read more here.
Keywords: catalyst controlled; synthesis bridged; bis; bis indolyl ... See more keywords