Development of novel bis-pyrazole derivatives as antitumor agents with potent apoptosis induction effects and DNA damage.
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DOI: 10.1016/j.ejmech.2017.11.098
Abstract: A series of bis-pyrazole derivatives were designed and synthesized, and their antitumor effects in vitro and in vivo were investigated. Several compounds displayed good antiproliferative activity with IC50 values in low-micromolar range against three human cancer cell… read more here.
Keywords: induction effects; dna damage; bis pyrazole; pyrazole derivatives ... See more keywords