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Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00422
Abstract: In this paper, a novel and efficient route for the synthesis of α,β-bis-sulfonyl arylketones via an NH2OH-HCl-mediated intermolecular umpolung α-methylsulfonylation of α-sulfonyl ketones with methylsulfoxides is described. A plausible mechanism is proposed and discussed. Various…
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Keywords:
nh2oh hcl;
bis sulfonyl;
sulfonyl;
synthesis bis ... See more keywords
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Published in 2021 at "Molecules"
DOI: 10.3390/molecules26020259
Abstract: A design strategy for macromolecular prodrugs is described, that are expected to exhibit robust activity against most solid tumor types while resulting in minimal toxicities to normal tissues. This approach exploits the enhanced permeability, and…
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Keywords:
design strategy;
bis sulfonyl;
sulfonyl alkylhydrazines;
tumor ... See more keywords