Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with in vivo and in silico study
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DOI: 10.1080/14756366.2023.2166936
Abstract: Abstract Bis-thiazole derivatives were synthesised conforming to the Pim1 pharmacophore model following Hantzsch condensation. Pim1 has a major role in regulating the G1/S phase which upon inhibition the cell cycle stops at its early stages.… read more here.
Keywords: thiazole derivatives; bis thiazole; pim1; cytotoxic evaluation ... See more keywords