Hydromorphone impurity 2,2-bishydromorphone does not exert mutagenic and clastogenic properties via in silico QSAR prediction and in vitro Ames and micronucleus test.
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DOI: 10.1080/01480545.2022.2076866
Abstract: The opioid agonist hydromorphone is indicated for the management of severe acute and chronic pain given that alternate treatments are insufficient. While the genotoxicity profile of hydromorphone is well investigated, little is known about the… read more here.
Keywords: vitro; silico; bishydromorphone; micronucleus test ... See more keywords