Development of Bisindole-Substituted Aminopyrazoles as Novel GSK-3β Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity.
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DOI: 10.1021/acschemneuro.0c00520
Abstract: Development of glycogen synthase kinase-3β (GSK-3β) inactivation-centric agents with ploypharmacological profiles is increasingly recognized as a promising therapeutic strategy against the multifactorial etiopathology of Alzheimer's disease (AD). In this respect, a series of disubstituted aminopyrazole… read more here.
Keywords: inflammation; oxidative neurotoxicity; gsk inhibitors; development ... See more keywords