Antitumor Activity of a Bispecific Chimera Targeting EGFR and Met in Gefitinib‐Resistant Non‐Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202402884
Abstract: Non‐small cell lung cancers (NSCLC) frequently acquire resistance to tyrosine kinase inhibitors (TKI) due to epidermal growth factor receptor (EGFR) mutation or activation of the bypass pathway involving mesenchymal‐epithelial transition factor (Met). To address this… read more here.
Keywords: non small; egfr met; chimera; small cell ... See more keywords
Improving Product Quality and Productivity of Bispecific Molecules Through the Application of Continuous Perfusion Principles.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology progress"
DOI: 10.1002/btpr.2973
Abstract: Bispecific protein scaffolds can be more complex than traditional monoclonal antibodies (MAbs) because two different sites/domains for epitope binding are needed. Because of this increased molecular complexity, bispecific molecules are difficult to express and can… read more here.
Keywords: perfusion; product; process; product quality ... See more keywords
Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Properties of Rozibafusp alfa, a Bispecific Inhibitor of BAFF and ICOSL: Analyses of Phase 1 Clinical Trials.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2929
Abstract: Rozibafusp alfa (AMG 570) is a first-in-class bispecific IgG2-peptide fusion designed to inhibit inducible T-cell costimulator ligand (ICOSL) and B-cell activating factor (BAFF). The pharmacokinetics (PK) and pharmacodynamics (PD) of rozibafusp alfa were investigated in… read more here.
Keywords: baff; rozibafusp alfa; bispecific; icosl ... See more keywords
Selection for Anti-transferrin Receptor Bispecific T-cell Engager in Different Molecular Formats
Sign Up to like & getrecommendations! Published in 2020 at "Current Medical Science"
DOI: 10.1007/s11596-020-2143-y
Abstract: Selecting an ideal molecular format from diverse structures is a major challenge in developing a bispecific antibody (BsAb). To choose an ideal format of anti-CD3 × anti-transferrin receptor (TfR) bispecific antibodies for clinical application, we… read more here.
Keywords: chain; bispecific cell; anti transferrin; cell engager ... See more keywords
A potential downstream platform approach for WuXiBody-based IgG-like bispecific antibodies.
Sign Up to like & getrecommendations! Published in 2020 at "Protein expression and purification"
DOI: 10.1016/j.pep.2020.105647
Abstract: WuXiBody is a novel bispecific antibody (bsAb) platform developed by WuXi Biologics. It enables almost any monoclonal antibody (mAb) sequence pair to be assembled into a bispecific construct. BsAbs based on WuXiBody can adopt either… read more here.
Keywords: platform approach; approach wuxibody; platform; wuxibody based ... See more keywords
End-To-End Automated Intact Protein Mass Spectrometry for High-Throughput Screening and Characterization of Bispecific and Multispecific Antibodies
Sign Up to like & getrecommendations! Published in 2024 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.4c04833
Abstract: Bispecific antibodies (bsAbs) and multispecific antibodies (msAbs) represent a promising frontier in therapeutic antibody development, offering unique capabilities not achievable with traditional monoclonal antibodies. Despite their potential, significant challenges remain due to their increased molecular… read more here.
Keywords: high throughput; end; multispecific antibodies; mass ... See more keywords
Rapid Systematic Screening of Bispecific Antibody Surrogate Geometries for T-Cell Engagement Using DNA Nanotechnology
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c11648
Abstract: Bispecific antibodies (bsAbs) are emerging immune-therapeutics, and many formats exist that differ considerably in structure. However, little systematic data exist about how the spatial organization of their components influences activity, requiring innovative approaches combining empirical… read more here.
Keywords: dna nanotechnology; cell engagement; surrogate geometries; nanotechnology ... See more keywords
SpyMask enables combinatorial assembly of bispecific binders
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-46599-9
Abstract: Bispecific antibodies are a successful and expanding therapeutic class, bridging two cell-types or engaging two different molecules on the same cell. Bispecifics unlock avenues towards synergy, resistance evasion, and signaling bias. Standard approaches to generate… read more here.
Keywords: enables combinatorial; bispecific; combinatorial assembly; geometry ... See more keywords
Characterization of anti-CD3 antibodies in clinically available bispecific T cell engagers.
Sign Up to like & getrecommendations! Published in 2025 at "Seminars in hematology"
DOI: 10.1053/j.seminhematol.2025.08.004
Abstract: Bispecific T cell engagers (bispecific TCEs) are engineered antibodies that redirect T cells to mediate tumor cell killing by simultaneously binding to CD3 on T cells and tumor-associated antigens. As of July 2025, ten bispecific… read more here.
Keywords: family; cd3; bispecific cell; bispecific tces ... See more keywords
Bispecific antibodies for the treatment of haemophilia A.
Sign Up to like & getrecommendations! Published in 2021 at "Expert opinion on biological therapy"
DOI: 10.1080/14712598.2021.1940133
Abstract: INTRODUCTION : Emicizumab is a bispecific antibody exerting cofactor function of FVIIIa irrespective of the presence of FVIII inhibitors. Long-term data of phase 1/2 and phase 3 studies have been accumulated. Various questions such as… read more here.
Keywords: treatment; antibodies treatment; treatment haemophilia; bispecific antibodies ... See more keywords
Bispecific antibody target pair discovery by high-throughput phenotypic screening using in vitro combinatorial Fab libraries
Sign Up to like & getrecommendations! Published in 2021 at "mAbs"
DOI: 10.1080/19420862.2020.1859049
Abstract: ABSTRACT Bispecific antibodies can uniquely influence cellular responses, but selecting target combinations for optimal functional activity remains challenging. Here we describe a high-throughput, combinatorial, phenotypic screening approach using a new bispecific antibody target discovery format,… read more here.
Keywords: target; bispecific; discovery; cell ... See more keywords