Geographic and Racial Disparities in Access to Chimeric Antigen Receptor–T Cells and Bispecific Antibodies Trials for Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.28877
Abstract: Key Points Question Is there equitable geographic access to chimeric antigen receptor–T cells (CAR-T) and bispecific antibodies trials for multiple myeloma in the US? Findings In this cross-sectional study of data from 69 clinical trials… read more here.
Keywords: trials multiple; multiple myeloma; antibodies trials; access chimeric ... See more keywords
Modulating Targeting of Poly(ethylene glycol) Particles to Tumor Cells Using Bispecific Antibodies.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201801607
Abstract: Low-fouling or "stealth" particles composed of poly(ethylene glycol) (PEG) display a striking ability to evade phagocytic cell uptake. However, functionalizing them for specific targeting is challenging. To address this challenge, stealth PEG particles prepared by… read more here.
Keywords: bispecific antibodies; poly ethylene; ethylene glycol; peg particles ... See more keywords
Computational design of a specific heavy chain/κ light chain interface for expressing fully IgG bispecific antibodies
Sign Up to like & getrecommendations! Published in 2017 at "Protein Science"
DOI: 10.1002/pro.3240
Abstract: The use of bispecific antibodies (BsAbs) to treat human diseases is on the rise. Increasingly complex and powerful therapeutic mechanisms made possible by BsAbs are spurring innovation of novel BsAb formats and methods for their… read more here.
Keywords: chain; production; fully igg; bispecific antibodies ... See more keywords
Bispecific Antibodies for the Treatment of Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Current Hematologic Malignancy Reports"
DOI: 10.1007/s11899-018-0472-8
Abstract: Purpose of reviewBispecific antibodies combine antigen recognition sites from two or more antibodies into a single construct allowing simultaneous binding to multiple targets. Bispecific antibodies exist which can redirect immune effector cells against acute myeloid… read more here.
Keywords: myeloid leukemia; treatment; antibodies treatment; bispecific antibodies ... See more keywords
Bispecific Antibodies in Hematologic Malignancies: When, to Whom, and How Should Be Best Used?
Sign Up to like & getrecommendations! Published in 2019 at "Current Oncology Reports"
DOI: 10.1007/s11912-019-0759-5
Abstract: Purpose of ReviewThe purpose of this review is to discuss the current recommendations for the use of bispecific antibodies (bsAb) in hematologic malignancies and explore the future in this field.Recent FindingsBispecific antibodies are molecules able… read more here.
Keywords: hematologic malignancies; bispecific antibodies; malignancies best; oncology ... See more keywords
T Cell-Redirecting Strategies to 'STAb' Tumors: Beyond CARs and Bispecific Antibodies.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in immunology"
DOI: 10.1016/j.it.2019.01.008
Abstract: The redirection of T cell activity towards cancer cells via targeting of tumor-associated antigens (TAAs) by soluble bispecific antibodies (bsAbs) or membrane-anchored chimeric antigen receptors is one of the most promising cancer immunotherapy strategies currently… read more here.
Keywords: cell redirecting; redirecting strategies; bispecific antibodies; stab tumors ... See more keywords
In vivo imaging of alpha-synuclein with antibody-based PET
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2022.108985
Abstract: The protein alpha-synuclein (αSYN) plays a central role in synucleinopathies such as Parkinsons's disease (PD) and multiple system atrophy (MSA). Presently, there are no selective αSYN positron emission tomography (PET) radioligands that do not also… read more here.
Keywords: syn; antibody based; bispecific antibodies; alpha synuclein ... See more keywords
Translating the Concept of Bispecific Antibodies to Engineering Heterodimeric Phosphotriesterases with Broad Organophosphate Substrate Recognition.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00751
Abstract: We have adopted the concept of bispecific antibodies, which can simultaneously block or cross-link two different biomolecular targets, to create bispecific enzymes by exploiting the homodimeric quaternary structure of bacterial phosphotriesterases (PTEs). The PTEs from… read more here.
Keywords: bispecific antibodies; concept bispecific; agents pesticides; nerve agents ... See more keywords
Viscosities and Protein Interactions of Bispecific Antibodies and Their Monospecific Mixtures.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00706
Abstract: Solution viscosities (η) and protein-protein interactions (PPI) of three monoclonal antibodies (mAb-A, mAb-B, mAb-C), two bispecific antibodies (BsAb-A/B, BsAb-A/C), and two 1:1 binary mixtures (mAb-A + mAb-B and mAb-A + mAb-C) were measured. mAb-A and… read more here.
Keywords: viscosity; mab mab; bispecific antibodies; mixture ... See more keywords
Engineering MMP-2 Activated Nanoparticles Carrying B7-H3 Bispecific Antibodies for Ferroptosis-Enhanced Glioblastoma Immunotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c12217
Abstract: Administration of bispecific antibodies (biAbs) in tumor therapy is limited by their short half-life and off-target toxicity. Optimized strategies or targets are needed to overcome these barriers. B7-H3 (CD276), a member of the B7 superfamily,… read more here.
Keywords: degcg nps; biab degcg; ferroptosis; degcg ... See more keywords
The use of bispecific antibodies to optimize the outcome of patients with acute leukemia, lymphoma and multiple myeloma after SCT
Sign Up to like & getrecommendations! Published in 2019 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-019-0596-z
Abstract: One of the remaining and unresolved problems in allogeneic stem cell transplantation, especially following a T cell-depleted transplant as often performed in the setting of haploidentical transplantation, is the relapse of the underlying hematological malignancy.… read more here.
Keywords: cell transplantation; stem cell; transplantation; bispecific antibodies ... See more keywords