Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor.
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DOI: 10.1016/j.toxlet.2017.10.024
Abstract: Irreversible inhibition of the acetylcholine esterase upon intoxication with organophosphorus compounds leads to an accumulation of acetylcholine in the synaptic cleft and a subsequent desensitization of nicotinic acetylcholine receptors which may ultimately result in respiratory… read more here.
Keywords: acetylcholine; nicotinic acetylcholine; bispyridinium compound; binding sites ... See more keywords