A mathematical model captures the role of adenyl cyclase Cyr1 and guanidine exchange factor Ira2 in creating a growth‐to‐hyphal bistable switch in Candida albicans
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13470
Abstract: Recent biochemical experiments have indicated that in Candida albicans, a commensal fungal pathogen, the Ras signaling pathway plays a significant role in the yeast‐to‐hyphal transition; specifically, two enzymes in this pathway, Adenyl Cyclase Cyr1 and GTPase… read more here.
Keywords: bistable switch; adenyl cyclase; switch; cyclase cyr1 ... See more keywords
A trypsin-based bistable switch
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.04.053
Abstract: Abstract Recreating some of the emergent behavior seen in biological reaction networks is an important goal in the new field of systems chemistry. One of the classic examples of complex behavior is bistability, which is… read more here.
Keywords: trypsin based; switch; bistable switch; based bistable ... See more keywords
A New Bistable Switch Model of Alzheimer’s Disease Pathogenesis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137061
Abstract: We propose a model to explain the pathogenesis of Alzheimer’s disease (AD) based on the theory that any disease affecting a healthy organism originates from a bistable feedback loop that shifts the system from a… read more here.
Keywords: bistable switch; disease; alzheimer disease; model ... See more keywords