Bisubstrate Kinetics of Glutathione S-Transferase: A Colorimetric Experiment for the Introductory Biochemistry Laboratory
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DOI: 10.1021/acs.jchemed.7b00535
Abstract: Most biochemical transformations involve more than one substrate. Bisubstrate enzymes catalyze multiple chemical reactions in living systems and include members of the transferase, oxidoreductase, and ligase enzyme classes. Working knowledge of bisubstrate enzyme kinetic models… read more here.
Keywords: biochemistry; bisubstrate; introductory biochemistry; glutathione transferase ... See more keywords
Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity
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DOI: 10.1021/acs.jmedchem.9b00413
Abstract: Nicotinamide N-methyltransferase (NNMT) catalyzes the methylation of nicotinamide to form N-methylnicotinamide. Overexpression of NNMT is associated with a variety of diseases, including a number of cancers and metabolic disorders, suggesting a role for NNMT as… read more here.
Keywords: bisubstrate; nicotinamide methyltransferase; activity; methyltransferase nnmt ... See more keywords
Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4)
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DOI: 10.1042/bcj20190826
Abstract: Attenuating the function of protein arginine methyltransferases (PRMTs) is an objective for the investigation and treatment of several diseases including cardiovascular disease and cancer. Bisubstrate inhibitors that simultaneously target binding sites for arginine substrate and… read more here.
Keywords: protein arginine; evaluation bisubstrate; bisubstrate; arginine methyltransferases ... See more keywords
Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4).
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical Journal"
DOI: 10.2210/pdb6s7c/pdb
Abstract: Attenuating the function of protein arginine methyltransferases (PRMTs) is an objective for the investigation and treatment of several diseases including cardiovascular disease and cancer. Bisubstrate inhibitors that simultaneously target binding sites for arginine substrate and… read more here.
Keywords: protein arginine; evaluation bisubstrate; bisubstrate; arginine methyltransferases ... See more keywords