Esterase-Sensitive Prodrugs of a Potent Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT) Display Cellular Activity
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DOI: 10.3390/biom11091357
Abstract: A recently discovered bisubstrate inhibitor of Nicotinamide N-methyltransferase (NNMT) was found to be highly potent in biochemical assays with a single digit nanomolar IC50 value but lacking in cellular activity. We, here, report a prodrug… read more here.
Keywords: cellular activity; bisubstrate inhibitor; nicotinamide methyltransferase; inhibitor nicotinamide ... See more keywords