T2R bitter taste receptors regulate apoptosis and may be associated with survival in head and neck squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13131
Abstract: Better management of head and neck squamous cell carcinomas (HNSCCs) requires a clearer understanding of tumor biology and disease risk. Bitter taste receptors (T2Rs) have been studied in several cancers, including thyroid, salivary, and GI,… read more here.
Keywords: neck squamous; taste receptors; squamous cell; bitter taste ... See more keywords
Evolution of the bitter taste receptor TAS2R38 in colobines
Sign Up to like & getrecommendations! Published in 2020 at "Primates"
DOI: 10.1007/s10329-020-00799-1
Abstract: Bitter taste perception enables the detection of potentially toxic molecules and thus evokes avoidance behavior in vertebrates. It is mediated by bitter taste receptors, TAS2Rs. One of the best-studied TAS2R is TAS2R38. Phenylthiocarbamide (PTC) perception… read more here.
Keywords: taste; sensitivity; african colobines; bitter taste ... See more keywords
Bitter taste receptors are expressed in human epithelial ovarian and prostate cancers cells and noscapine stimulation impacts cell survival
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-018-3464-z
Abstract: Bitter taste receptors (Tas2Rs) are a subfamily of G-protein coupled receptors expressed not only in the oral cavity but also in several extra-oral tissues and disease states. Several natural bitter compounds from plants, such as… read more here.
Keywords: epithelial ovarian; taste receptors; receptors expressed; ovarian prostate ... See more keywords
Taste perception and expression in stomach of bitter taste receptor tas2r38 in obese and lean subjects
Sign Up to like & getrecommendations! Published in 2021 at "Appetite"
DOI: 10.1016/j.appet.2021.105595
Abstract: Differences in taste perception have been related to eating behavior, nutritional status, and diseases. Recently, taste receptors have been identified in several extra-oral tissues, such as the gastrointestinal tract, where they seem to influence processes… read more here.
Keywords: taste; taste perception; expression; taste receptor ... See more keywords
Application of a salt substitute in bitter taste suppression and toward better acceptance of cruciferous vegetables in diet
Sign Up to like & getrecommendations! Published in 2022 at "Appetite"
DOI: 10.1016/j.appet.2022.105996
Abstract: The addition of table salt has been reported to enable better acceptance when consuming the least preferred vegetables belonging to the Cruciferae family. Considering the adverse effect of excessive table salt intake on incidence of… read more here.
Keywords: better acceptance; cruciferous vegetables; bitter taste; salt substitute ... See more keywords
The druggability of bitter taste receptors for the treatment of neurodegenerative disorders.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2022.114915
Abstract: The delivery of therapeutic drugs to the brain remains a major pharmacology challenge. A complex system of chemical surveillance to protect the brain from endogenous and exogenous toxicants at brain barriers hinders the uptake of… read more here.
Keywords: bitter taste; treatment; pharmacology; brain ... See more keywords
Hen protein-derived peptides as the blockers of human bitter taste receptors T2R4, T2R7 and T2R14.
Sign Up to like & getrecommendations! Published in 2019 at "Food chemistry"
DOI: 10.1016/j.foodchem.2019.01.059
Abstract: Bitter sensation is mediated by various bitter taste receptors (T2Rs), thus T2R antagonists are actively explored. Our objective was to look for novel T2R blockers in hen protein hydrolysate (HPH). We screened the least bitter… read more here.
Keywords: t2r4 t2r7; taste receptors; hen protein; t2r7 t2r14 ... See more keywords
Bitter taste in silico: A review on virtual ligand screening and characterization methods for TAS2R-bitterant interactions.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120486
Abstract: The growing pharmaceutical interest in the human bitter taste receptors (hTAS2Rs) has two dimensions; i) evaluation the bitterness of active pharmaceutical compounds, in order to develop strategies for improving patients' adherence to medication, and ii)… read more here.
Keywords: taste; taste silico; silico review; bitter taste ... See more keywords
Multi-scale simulations of membrane proteins: The case of bitter taste receptors
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Science: Advanced Materials and Devices"
DOI: 10.1016/j.jsamd.2017.03.001
Abstract: Abstract Human bitter taste receptors (hTAS2Rs) are the second largest group of chemosensory G-protein coupled receptors (25 members). hTAS2Rs are expressed in many tissues (e.g. tongue, gastrointestinal tract, respiratory system, brain, etc.), performing a variety… read more here.
Keywords: taste; taste receptors; case; site ... See more keywords
Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.10.047
Abstract: Bitter taste serves as an important signal for potentially poisonous compounds in foods to avoid their ingestion. Thousands of compounds are estimated to taste bitter and presumed to activate taste receptor cells expressing bitter taste… read more here.
Keywords: taste; gustducin positive; positive taste; responses gustducin ... See more keywords
The taste of neuroinflammation: molecular mechanisms linking taste sensing to neuroinflammatory responses.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105557
Abstract: Evidence indicates a critical role of neuroinflammatory response as an underlying pathophysiological process in several central nervous system disorders, including neurodegenerative diseases. However, the molecular mechanisms that trigger neuroinflammatory processes are not fully known. The… read more here.
Keywords: taste; neuroinflammatory responses; taste receptor; molecular mechanisms ... See more keywords