Non‐canonical bivalent H3K4me3K9me3 recognition by Spindlin1/C11orf84 complex
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202100229
Abstract: Bivalent chromatin with active H3K4me3 and repressive H3K27me3 was initially identified in embryonic stem cells (ESCs) to poise expression of developmental genes upon lineage commitment. Since then, many more different bivalent modifications have been demonstrated… read more here.
Keywords: spindlin1 c11orf84; non canonical; bivalent; c11orf84 complex ... See more keywords
Artificially designed hepatitis B virus core particles composed of multiple epitopes of type A and O foot‐and‐mouth disease virus as a bivalent vaccine candidate
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25554
Abstract: Recently, many countries, including China, have experienced a series of type A and O foot‐and‐mouth disease virus (FMDV) epidemics, causing serious economic losses. Although concerns about the safety of inactivated FMD vaccines have been raised,… read more here.
Keywords: type foot; foot mouth; bivalent; type ... See more keywords
Changes in Potency and Subtype Selectivity of Bivalent NaV Toxins are Knot-Specific.
Sign Up to like & getrecommendations! Published in 2023 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.3c00135
Abstract: Disulfide-rich peptide toxins have long been studied for their ability to inhibit voltage-gated sodium channel subtype NaV1.7, a validated target for the treatment of pain. In this study, we sought to combine the pore blocking… read more here.
Keywords: subtype selectivity; ligation; chemistry; gating modifier ... See more keywords
Understanding Mono- and Bivalent Ion Selectivities of Nanoporous Graphene Using Ionic and Bi-ionic Potentials
Sign Up to like & getrecommendations! Published in 2020 at "Langmuir"
DOI: 10.1021/acs.langmuir.0c00924
Abstract: Nanoporous graphene displays salt-dependent ion permeation. In this work, we investigate the differences in Donnan potentials arising between reservoirs, separated by a perforated graphene membrane, containing different cations. We compare the case of monovalent cations… read more here.
Keywords: strength; nanoporous graphene; graphene; ion ... See more keywords
pH-Sensitive and Biodegradable Mn3(PO4)2·3H2O Nanoparticles as an Adjuvant of Protein-Based Bivalent COVID-19 Vaccine to Induce Potent and Broad-Spectrum Immunity
Sign Up to like & getrecommendations! Published in 2023 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.2c19736
Abstract: Developing a novel and potent adjuvant with great biocompatibility for immune response augmentation is of great significance to enhance vaccine efficacy. In this work, we prepared a long-term stable, pH-sensitive, and biodegradable Mn3(PO4)2·3H2O nanoparticle (nano-MnP)… read more here.
Keywords: sensitive biodegradable; bivalent; vaccine; nano mnp ... See more keywords
Site-Specific Linking of an Oligonucleotide to Mono- and Bivalent Recombinant Antibodies with SpyCatcher-SpyTag System for Immuno-PCR
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c03750
Abstract: Antibody-oligonucleotide conjugates (AOCs) are a versatile class of chimeric biomolecules for therapeutics and biotechnological applications. Most widely employed chemical labeling methods for proteins are based on targeting of Lys or Cys residues that leads to… read more here.
Keywords: site specific; immuno pcr; site; bivalent ... See more keywords
Structure-Guided Designing Pre-Organization in Bivalent Aptamers.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12593
Abstract: Multivalent interaction is often used in molecular design and leads to engineered multivalent ligands with increased binding avidities toward target molecules. The resulting binding avidity relies critically on the rigid scaffold that joins multiple ligands… read more here.
Keywords: design; structure guided; bivalent; pre organization ... See more keywords
Structural mechanism of bivalent histone H3K4me3K9me3 recognition by the Spindlin1/C11orf84 complex in rRNA transcription activation
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21236-x
Abstract: Spindlin1 is a unique multivalent epigenetic reader that facilitates ribosomal RNA transcription. In this study, we provide molecular and structural basis by which Spindlin1 acts in complex with C11orf84 to preferentially recognize non-canonical bivalent mark… read more here.
Keywords: transcription; c11orf84 complex; c11orf84; spindlin1 c11orf84 ... See more keywords
Activation of bivalent factor DLX5 cooperates with master regulator TP63 to promote squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab679
Abstract: Abstract To reconstruct systematically hyperactive transcription factor (TF)-dependent transcription networks in squamous cell carcinomas (SCCs), a computational method (ELMER) was applied to 1293 pan-SCC patient samples, and 44 hyperactive SCC TFs were identified. As a… read more here.
Keywords: dlx5 cooperates; squamous cell; bivalent; factor ... See more keywords
Decoding the function of bivalent chromatin in development and cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Genome research"
DOI: 10.1101/gr.275736.121
Abstract: Bivalent chromatin is characterized by the simultaneous presence of H3K4me3 and H3K27me3, histone modifications generally associated with transcriptionally active and repressed chromatin, respectively. Prevalent in embryonic stem cells (ESCs), bivalency is postulated to poise/prime lineage-controlling… read more here.
Keywords: bivalent; bivalency; h3k4me3; bivalent chromatin ... See more keywords
Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abm0730
Abstract: Bivalent genes are ready for activation upon the arrival of developmental cues. Here, we report that BEND3 is a CpG island (CGI)–binding protein that is enriched at regulatory elements. The cocrystal structure of BEND3 in… read more here.
Keywords: bivalent genes; premature activation; bend3; bivalent ... See more keywords