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   Articles with "bivalent" as a keyword



Non‐canonical bivalent H3K4me3K9me3 recognition by Spindlin1/C11orf84 complex

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recommendations! Published in 2022 at "BioEssays"

DOI: 10.1002/bies.202100229

Abstract: Bivalent chromatin with active H3K4me3 and repressive H3K27me3 was initially identified in embryonic stem cells (ESCs) to poise expression of developmental genes upon lineage commitment. Since then, many more different bivalent modifications have been demonstrated… read more here.

Keywords: spindlin1 c11orf84; non canonical; bivalent; c11orf84 complex ... See more keywords

Artificially designed hepatitis B virus core particles composed of multiple epitopes of type A and O foot‐and‐mouth disease virus as a bivalent vaccine candidate

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recommendations! Published in 2019 at "Journal of Medical Virology"

DOI: 10.1002/jmv.25554

Abstract: Recently, many countries, including China, have experienced a series of type A and O foot‐and‐mouth disease virus (FMDV) epidemics, causing serious economic losses. Although concerns about the safety of inactivated FMD vaccines have been raised,… read more here.

Keywords: type foot; foot mouth; bivalent; type ... See more keywords

Changes in Potency and Subtype Selectivity of Bivalent NaV Toxins are Knot-Specific.

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recommendations! Published in 2023 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.3c00135

Abstract: Disulfide-rich peptide toxins have long been studied for their ability to inhibit voltage-gated sodium channel subtype NaV1.7, a validated target for the treatment of pain. In this study, we sought to combine the pore blocking… read more here.

Keywords: subtype selectivity; ligation; chemistry; gating modifier ... See more keywords

Bivalent Hapten Display Strategies for Conjugate Vaccines Targeting Opioid Mixtures Containing Fentanyl.

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recommendations! Published in 2025 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.4c00548

Abstract: Increasingly, street mixtures of opioids are reported to contain combinations of synthetic opioids, such as fentanyl with fentanyl analogues or counterfeit oxycodone pills containing fentanyl. While antiopioid immunotherapeutics have been investigated as a possible approach… read more here.

Keywords: bivalent; containing fentanyl; target opioids; vaccines targeting ... See more keywords

Understanding Mono- and Bivalent Ion Selectivities of Nanoporous Graphene Using Ionic and Bi-ionic Potentials

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recommendations! Published in 2020 at "Langmuir"

DOI: 10.1021/acs.langmuir.0c00924

Abstract: Nanoporous graphene displays salt-dependent ion permeation. In this work, we investigate the differences in Donnan potentials arising between reservoirs, separated by a perforated graphene membrane, containing different cations. We compare the case of monovalent cations… read more here.

Keywords: strength; nanoporous graphene; graphene; ion ... See more keywords

pH-Sensitive and Biodegradable Mn3(PO4)2·3H2O Nanoparticles as an Adjuvant of Protein-Based Bivalent COVID-19 Vaccine to Induce Potent and Broad-Spectrum Immunity

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recommendations! Published in 2023 at "ACS Applied Materials & Interfaces"

DOI: 10.1021/acsami.2c19736

Abstract: Developing a novel and potent adjuvant with great biocompatibility for immune response augmentation is of great significance to enhance vaccine efficacy. In this work, we prepared a long-term stable, pH-sensitive, and biodegradable Mn3(PO4)2·3H2O nanoparticle (nano-MnP)… read more here.

Keywords: sensitive biodegradable; bivalent; vaccine; nano mnp ... See more keywords

Site-Specific Linking of an Oligonucleotide to Mono- and Bivalent Recombinant Antibodies with SpyCatcher-SpyTag System for Immuno-PCR

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recommendations! Published in 2020 at "ACS Omega"

DOI: 10.1021/acsomega.0c03750

Abstract: Antibody-oligonucleotide conjugates (AOCs) are a versatile class of chimeric biomolecules for therapeutics and biotechnological applications. Most widely employed chemical labeling methods for proteins are based on targeting of Lys or Cys residues that leads to… read more here.

Keywords: site specific; immuno pcr; site; bivalent ... See more keywords

Structure-Guided Designing Pre-Organization in Bivalent Aptamers.

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recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.1c12593

Abstract: Multivalent interaction is often used in molecular design and leads to engineered multivalent ligands with increased binding avidities toward target molecules. The resulting binding avidity relies critically on the rigid scaffold that joins multiple ligands… read more here.

Keywords: design; structure guided; bivalent; pre organization ... See more keywords

Rewiring the Fusion Oncoprotein EWSR1::FLI1 in Ewing Sarcoma with Bivalent Small Molecules.

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recommendations! Published in 2025 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.5c05634

Abstract: Dysregulated transcription is a defining hallmark of cancer. Recently, novel chemically induced proximity approaches have enabled the rewiring of transcriptional machinery to drive expression of pro-apoptotic genes using bivalent small molecules. In this work, we… read more here.

Keywords: bivalent; fusion; ewsr1 fli1; bivalent small ... See more keywords

Structural mechanism of bivalent histone H3K4me3K9me3 recognition by the Spindlin1/C11orf84 complex in rRNA transcription activation

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recommendations! Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-21236-x

Abstract: Spindlin1 is a unique multivalent epigenetic reader that facilitates ribosomal RNA transcription. In this study, we provide molecular and structural basis by which Spindlin1 acts in complex with C11orf84 to preferentially recognize non-canonical bivalent mark… read more here.

Keywords: transcription; c11orf84 complex; c11orf84; spindlin1 c11orf84 ... See more keywords

Development of bivalent RBD adapted COVID-19 vaccines for broad sarbecovirus immunity

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recommendations! Published in 2025 at "NPJ Vaccines"

DOI: 10.1038/s41541-025-01156-3

Abstract: COVID-19 vaccine adaptation is critical to respond to continuously emerging SARS-CoV-2 variants with enhanced immune evasion. The ARVAC protein subunit vaccine, based on the receptor binding domain of the spike protein of SARS-CoV-2, has been… read more here.

Keywords: sars cov; immunity; bivalent; sarbecovirus immunity ... See more keywords