Circular Bivalent Aptamers Enable in Vivo Stability and Recognition.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b04547
Abstract: Aptamers are powerful candidates for molecular imaging and targeted therapy of cancer based on such appealing features as high binding affinity, high specificity, site-specific modification and rapid tumor penetration. However, aptamers are susceptible to plasma… read more here.
Keywords: enable vivo; bivalent aptamers; aptamers enable; circular bivalent ... See more keywords
Bioinspired molecular engineering of bivalent aptamers by ligand-induced self-dimerization.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc05799a
Abstract: A bioinspired "point-and-shoot" molecular strategy is described for engineering noncovalent aptamers via K+-induced reassembly of a split G-quadruplex sequence at the end of monomeric aptamers. This design compensates for insufficient cell recognition of monovalent aptamers… read more here.
Keywords: bivalent aptamers; molecular engineering; bioinspired molecular; aptamers ligand ... See more keywords