Bivalent Ligand Aiming Putative Mu Opioid Receptor and Chemokine Receptor CXCR4 Dimers in Opioid Enhanced HIV-1 Entry.
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DOI: 10.1021/acsmedchemlett.0c00444
Abstract: A bivalent compound 1a featuring both a mu opioid receptor (MOR) and a CXCR4 antagonist pharmacophore (naltrexone and IT1t) was designed and synthesized. Further binding and functional studies demonstrated 1a acting as a MOR and… read more here.
Keywords: cxcr4; mor cxcr4; bivalent ligand; receptor ... See more keywords