Biophysical and Sequence-Based Methods for Identifying Monovalent and Bivalent Antibodies with High Colloidal Stability.
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DOI: 10.1021/acs.molpharmaceut.7b00779
Abstract: In vitro antibody discovery and/or affinity maturation are often performed using antibody fragments (Fabs), but most monovalent Fabs are reformatted as bivalent IgGs (monoclonal antibodies, mAbs) for therapeutic applications. One problem related to reformatting antibodies… read more here.
Keywords: antibody; association; biophysical properties; reformatted bivalent ... See more keywords