Rewiring the Fusion Oncoprotein EWSR1::FLI1 in Ewing Sarcoma with Bivalent Small Molecules.
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DOI: 10.1021/jacs.5c05634
Abstract: Dysregulated transcription is a defining hallmark of cancer. Recently, novel chemically induced proximity approaches have enabled the rewiring of transcriptional machinery to drive expression of pro-apoptotic genes using bivalent small molecules. In this work, we… read more here.
Keywords: bivalent; fusion; ewsr1 fli1; bivalent small ... See more keywords