Underlying mechanisms preserving coronary basal tone and NO-mediated relaxation in obesity: Involvement of β1 subunit-mediated upregulation of BKCa channels.
Sign Up to like & getrecommendations! Published in 2017 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2017.06.354
Abstract: BACKGROUND AND AIMS The impact of obesity on vasomotor regulation of coronary arteries and its underlying mechanisms are not completely understood and, in particular, the role of BKCa channels in the NO-mediated coronary vasodilation in… read more here.
Keywords: coronary arteries; tone; channel; bkca channels ... See more keywords
Potential Involvement of Impaired BKCa Channel Function in Sensory Defensiveness and Some Behavioral Disturbances Induced by Unfamiliar Environment in a Mouse Model of Fragile X Syndrome
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DOI: 10.1038/npp.2017.149
Abstract: In fragile X syndrome (FXS), sensory hypersensitivity and impaired habituation is thought to result in attention overload and various behavioral abnormalities in reaction to the excessive and remanent salience of environment features that would normally… read more here.
Keywords: fragile syndrome; sensory hypersensitivity; sensory defensiveness; bkca channel ... See more keywords
Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes
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DOI: 10.1038/s41598-017-14565-9
Abstract: Large-conductance Ca2+-activated potassium (BKCa) channels are key determinants of vascular smooth muscle excitability. Impaired BKCa channel function through remodeling of BKCa β1 expression and function contributes to vascular complications in animal models of diabetes. Yet,… read more here.
Keywords: vascular smooth; channel; smooth muscle; function ... See more keywords
A14018 Chronic hypoxia during gestation increases uterine vascular resistance and maternal blood pressure
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DOI: 10.1097/01.hjh.0000548300.55242.7f
Abstract: Objectives: We determined the effect of chronic hypoxia during gestation on uterine vascular resistance and maternal blood pressure. Methods: The study was performed in sheep acclimatized to high altitude. Results: We demonstrated that high altitude… read more here.
Keywords: hypoxia; bkca channel; blood pressure;
Chronic exercise mediates epigenetic suppression of L-type Ca2+ channel and BKCa channel in mesenteric arteries of hypertensive rats.
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DOI: 10.1097/hjh.0000000000002457
Abstract: BACKGROUND Regular exercise is a lifestyle intervention for controlling hypertension and has an improving effect on vascular function. Voltage-gated L-type Ca (LTCC) and large-conductance Ca-activated K (BKCa) channels are two principal mediators of vascular smooth… read more here.
Keywords: hypertension; mesenteric arteries; bkca channel; exercise ... See more keywords
Pregnancy Reprograms Large-Conductance Ca2+-Activated K+ Channel in Uterine ArteriesNovelty and Significance
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DOI: 10.1161/hypertensionaha.117.09059
Abstract: The large-conductance Ca2+-activated K+ (BKCa) channel is of critical importance in pregnancy-mediated increase in uterine artery vasodilation and blood flow. The present study tested the hypothesis that active DNA demethylation plays a key role in… read more here.
Keywords: uterine arteries; pregnancy; large conductance; expression ... See more keywords
Permissive Modulation of Sphingosine-1-Phosphate-Enhanced Intracellular Calcium on BKCa Channel of Chromaffin Cells
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DOI: 10.3390/ijms22042175
Abstract: Sphingosine-1-phosphate (S1P), is a signaling sphingolipid which acts as a bioactive lipid mediator. We assessed whether S1P had multiplex effects in regulating the large-conductance Ca2+-activated K+ channel (BKCa) in catecholamine-secreting chromaffin cells. Using multiple patch-clamp… read more here.
Keywords: s1p; bkca channel; chromaffin cells; bkca ... See more keywords