Translating peripheral bladder afferent mechanosensitivity to neuronal activation within the lumbosacral spinal cord of mice
Sign Up to like & getrecommendations! Published in 2019 at "PAIN"
DOI: 10.1097/j.pain.0000000000001453
Abstract: Abstract Primary afferent neurons transduce distension of the bladder wall into action potentials that are relayed into the spinal cord and brain, where autonomic reflexes necessary for maintaining continence are coordinated with pathways involved in… read more here.
Keywords: bladder afferent; bladder; dorsal horn; spinal cord ... See more keywords
Nerve growth factor‐dependent hyperexcitability of capsaicin‐sensitive bladder afferent neurones in mice with spinal cord injury
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DOI: 10.1113/ep086951
Abstract: What is the central question of this study? Nerve growth factor (NGF) is reportedly a mediator inducing urinary bladder dysfunction. Is NGF directly involved in hyperexcitability of capsaicin‐sensitive C‐fibre bladder afferent pathways after spinal cord… read more here.
Keywords: bladder afferent; hyperexcitability capsaicin; bladder; capsaicin sensitive ... See more keywords
Activation of uroepithelial 5-HT4R inhibits mechanosensory activity of murine bladder afferent nerves
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.990178
Abstract: Serotonin (5-HT) is known to act via multiple 5-HT receptors at spinal and supraspinal levels to regulate micturition. However, the contribution of peripheral 5-HT and its receptors in bladder physiology and pathology is not very… read more here.
Keywords: bladder; bladder afferent; afferent nerves; cyp treated ... See more keywords