Novel One-Pot Cyclization of the Blaise Reaction Intermediate and Arylglyoxals: The Synthesis of Substituted NH-Pyrroles
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DOI: 10.1055/s-0036-1588168
Abstract: A novel tandem Blaise reaction for the one-pot synthesis of substituted NH-pyrroles was described. The Blaise reaction intermediate, generated in situ from Reformatsky reagent and nitrile, reacted with arylglyoxals chemoselectively to afford a wide variety… read more here.
Keywords: blaise reaction; substituted pyrroles; reaction intermediate; synthesis substituted ... See more keywords
Practical Synthesis of Functionalized Chromeno[3,4-c]pyridine Derivatives via a CuCl2-Catalyzed Tandem Reaction of the Blaise Reaction Intermediates and 3-Cyanocoumarins
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DOI: 10.1055/s-0036-1591535
Abstract: This work discloses a novel and eļ¬cient protocol for the construction of functionalized chromeno[3,4-c]pyridine derivatives from the Blaise reaction intermediates and 3-cyanocoumarins through a CuCl2-catalyzed sequential Michael addition/intramolecular cyclization/oxidative aromatization reaction. This new method shows… read more here.
Keywords: reaction intermediates; blaise reaction; functionalized chromeno; chromeno pyridine ... See more keywords
Vinylogous Blaise Reaction: Conceptually New Synthesis of Pyridin-2-ones
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DOI: 10.1055/s-0037-1610171
Abstract: A conceptually new synthesis of pyridine rings by a [C4 + CN] assembly has been developed by applying a vinylogous version of the classic Blaise reaction. The zinc-mediated reaction of (het)aryl or alkyl nitriles with… read more here.
Keywords: new synthesis; blaise reaction; pyridin ones; reaction ... See more keywords