Association of blaNDM-1 with blaKPC-2 and aminoglycoside-modifying enzymes genes among Klebsiella pneumoniae, Proteus mirabilis and Serratia marcescens clinical isolates in Brazil.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2019.08.026
Abstract: OBJECTIVE Carbapenemase producingEnterobacterales are often involved in healthcare-associated infections worldwide. Therefore, the objective of this study was to investigate the frequency of the main genes for carbapenemases, methylases, aminoglycoside-modifying enzymes (AMEs), and mcr gene, as… read more here.
Keywords: blandm blakpc; modifying enzymes; aminoglycoside modifying; mirabilis ... See more keywords
Plasmid diversity among genetically related Klebsiella pneumoniae blaKPC-2 and blaKPC-3 isolates collected in the Dutch national surveillance
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-73440-2
Abstract: Carbapenemase-producing Klebsiella pneumoniae emerged as a nosocomial pathogen causing morbidity and mortality in patients. For infection prevention it is important to track the spread of K. pneumoniae and its plasmids between patients. Therefore, the major… read more here.
Keywords: pneumoniae blakpc; blakpc blakpc; pneumoniae; blakpc isolates ... See more keywords
Within patient genetic diversity of blaKPC harboring Klebsiellapneumoniae in a Colombian hospital and identification of a new NTEKPC platform
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00887-2
Abstract: Resistance to carbapenems in Klebsiella pneumoniae has been mostly related with the worldwide dissemination of KPC, largely due to the pandemic clones belonging to the complex clonal (CC) 258. To unravel blaKPC post-endemic clinical impact,… read more here.
Keywords: patient genetic; genetic diversity; within patient; blakpc ... See more keywords
Plasmid Promiscuity Explains High Endemicity of KPC-2 Among Colombian Enterobacteriaceae
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DOI: 10.1093/ofid/ofx163.1581
Abstract: Abstract Background Carbapenemase-producing Enterobacteriaceae (CPE) currently pose a significant global public health threat. KPC carbapenemases are highly endemic in Colombia mostly among Enterobacteriaceae. In Klebsiella pneumoniae (Kpn), horizontal transfer of genes encoding KPC and expansion… read more here.
Keywords: research; research support; high endemicity; blakpc ... See more keywords
Genomic epidemiology of carbapenem-resistant Enterobacterales at a New York City hospital over a 10-year period reveals complex plasmid-clone dynamics and evidence for frequent horizontal transfer of blaKPC
Sign Up to like & getrecommendations! Published in 2024 at "Genome Research"
DOI: 10.1101/gr.279355.124
Abstract: Transmission of carbapenem-resistant Enterobacterales (CRE) in hospitals has been shown to occur through complex, multifarious networks driven by both clonal spread and horizontal transfer mediated by plasmids and other mobile genetic elements. We performed nanopore… read more here.
Keywords: epidemiology; resistant enterobacterales; plasmid; carbapenem resistant ... See more keywords
Emergence and Evolution of Multidrug-Resistant Klebsiella pneumoniae with both blaKPC and blaCTX-M Integrated in the Chromosome
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00076-17
Abstract: ABSTRACT The extended-spectrum-β-lactamase (ESBL)- and Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae represent serious and urgent threats to public health. In a retrospective study of multidrug-resistant K. pneumoniae, we identified three clinical isolates, CN1, CR14, and NY9,… read more here.
Keywords: blactx; pneumoniae; blactx integrated; multidrug resistant ... See more keywords
Citrobacter spp. and Enterobacter spp. as reservoirs of carbapenemase blaNDM and blaKPC resistance genes in hospital wastewater
Sign Up to like & getrecommendations! Published in 2024 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.01165-24
Abstract: ABSTRACT Antibiotic resistance has emerged as a global threat to public health, generating a growing interest in investigating the presence of antibiotic-resistant bacteria in environments influenced by anthropogenic activities. Wastewater treatment plants in hospital serve… read more here.
Keywords: resistance; resistance genes; hospital wastewater; blandm ... See more keywords
Analyses of a Ceftazidime-Avibactam-Resistant Citrobacter freundii Isolate Carrying blaKPC-2 Reveals a Heterogenous Population and Reversible Genotype
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DOI: 10.1128/msphere.00408-18
Abstract: The development of ceftazidime-avibactam resistance among KPC-producing isolates during treatment with this agent has been reported. Usually isolates that become resistant have a mutated blaKPC gene that confers resistance to ceftazidime-avibactam and susceptibility to meropenem.… read more here.
Keywords: ceftazidime avibactam; avibactam resistance; citrobacter freundii; blakpc ... See more keywords
Emergence and Expansion of a Carbapenem-Resistant Pseudomonas aeruginosa Clone Are Associated with Plasmid-Borne blaKPC-2 and Virulence-Related Genes
Sign Up to like & getrecommendations! Published in 2021 at "mSystems"
DOI: 10.1128/msystems.00154-21
Abstract: Health care-associated infections, also known as nosocomial infections, are the most frequent adverse events in health care delivery worldwide, causing high rates of morbidity and mortality and high health care costs. Pseudomonas aeruginosa is one… read more here.
Keywords: crpa; health; blakpc; health care ... See more keywords
An XDR Pseudomonas aeruginosa ST463 Strain with an IncP-2 Plasmid Containing a Novel Transposon Tn6485f Encoding blaIMP-45 and blaAFM-1 and a Second Plasmid with Two Copies of blaKPC-2
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.04462-22
Abstract: The ST463 clone is an emerging high-risk sequence type that is spreading with blaKPC-2-containing plasmids. The core blaKPC-2 genetic platform is ISKpn27-blaKPC-2-ISKpn6 in almost all samples, and the adjacent region beyond the core platform varies… read more here.
Keywords: blakpc; plasmid; blaimp blaafm; two copies ... See more keywords
Bloodstream infections caused by Klebsiella pneumoniae: prevalence of blaKPC, virulence factors and their impacts on clinical outcome
Sign Up to like & getrecommendations! Published in 2018 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-018-3263-x
Abstract: BackgroundKlebsiella pneumoniae bloodstream infections (BSIs) occur with significant prevalence and high mortality worldwide. Antimicrobial resistance and virulence are two main factors participating in the pathogenicity of K. pneumoniae. Here we investigated the prevalence of blaKPC… read more here.
Keywords: prevalence blakpc; hmkp; blakpc blakpc; pneumoniae ... See more keywords