T‐cell blast crisis of chronic myelogenous leukemia presented with coexisting p210 and p190 BCR‐ABL transcripts and t(10;11)(q11;p15)
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23241
Abstract: Blast transformation of chronic myelogenous leukemia (CML) to T lymphoblastic lymphoma/acute lymphoblastic leukemia (T‐LBL/ALL) is rare, and the molecular mechanism is still unclear. read more here.
Keywords: cell blast; blast crisis; chronic myelogenous; myelogenous leukemia ... See more keywords
Histone demethylase RBP2 mediates the blast crisis of chronic myeloid leukemia through an RBP2/PTEN/BCR-ABL cascade.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2019.109360
Abstract: Epigenetic disorders play a key role in tumorigenesis and development, among which histone methylation abnormalities are common. While patients living with chronic myeloid leukemia in the chronic phase (CML-CP) have a good response to TKI,… read more here.
Keywords: blast crisis; rbp2; bcr abl; expression ... See more keywords
Myodesopsia is a symptom of central nervous system blast crisis in chronic myeloid leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Leukemia Research Reports"
DOI: 10.1016/j.lrr.2019.03.001
Abstract: Highlights • Patient with chronic myeloid leukemia in the chronic phase developed myodesopsia.• Patient was in molecular response in bone marrow.• It was an isolated central nervous system blast crisis. read more here.
Keywords: blast crisis; nervous system; myeloid leukemia; central nervous ... See more keywords
Long: molecular tracking of CML with bilineal inv(16) myeloid and del(9) lymphoid blast crisis and durable response to CD19-directed CAR-T therapy
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-0983-x
Abstract: Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of chronic myeloid leukemia (CML), allowing most patients to remain in deep remission with an associated near normal life expectancy. Despite these advances, five to ten percent… read more here.
Keywords: cd19; cml; blast crisis; therapy ... See more keywords
Chronic myelod leukemia in chronic phase (CML-CP) with lymphadenopathy at diagnosis: A retrospective analysis
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DOI: 10.1093/annonc/mdz427.010
Abstract: Abstract Background Lymphadenpathy is a very unusual manifestation of CML-CP with an unclear implication on prognosis. We sought to understand the occurrence of this phenomenon and its effect on prognosis in newly diagnosed cases of… read more here.
Keywords: blast crisis; retrospective analysis; cml; diagnosis ... See more keywords
Pediatric Chronic Myelogenous Leukemia in T-lineage Blast Crisis: A Reminder in Relevance
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DOI: 10.1097/mph.0000000000002271
Abstract: Pediatric Philadelphia chromosome positive (Ph+) acute T-cell lymphoblastic leukemia can mimic chronic myelogenous leukemia (CML) in T-lineage blast crisis (BC). Differentiating the 2 is critical in guiding therapy as most children with de novo Ph+… read more here.
Keywords: leukemia; lineage; lineage blast; chronic myelogenous ... See more keywords
Hoxa9 and Hoxa10 induce CML myeloid blast crisis development through activation of Myb expression
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DOI: 10.18632/oncotarget.22008
Abstract: Mechanisms underlying the progression of Chronic Myeloid Leukemia (CML) from chronic phase to myeloid blast crisis are poorly understood. Our previous studies have suggested that overexpression of SETBP1 can drive this progression by conferring unlimited… read more here.
Keywords: blast crisis; myeloid blast; myeloid; cml ... See more keywords