Acquisition of a Unique Mesenchymal Precursor-like Blastema State Underlies Successful Adult Mammalian Digit Tip Regeneration.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.12.004
Abstract: Here, we investigate the origin and nature of blastema cells that regenerate the adult murine digit tip. We show that Pdgfra-expressing mesenchymal cells in uninjured digits establish the regenerative blastema and are essential for regeneration.… read more here.
Keywords: digit; blastema; regeneration; digit tip ... See more keywords
Transcriptomic landscape of the blastema niche in regenerating adult axolotl limbs at single-cell resolution
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07604-0
Abstract: Regeneration of complex multi-tissue structures, such as limbs, requires the coordinated effort of multiple cell types. In axolotl limb regeneration, the wound epidermis and blastema have been extensively studied via histology, grafting, and bulk-tissue RNA-sequencing.… read more here.
Keywords: single cell; blastema; regeneration; adult axolotl ... See more keywords
Preparation of three-dimensional matrices of human gingival tissue and comparison of induction of mesenchymal and blastema stem cell behaviors in prepared scaffolds.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2022.68.1.13
Abstract: This study aimed to compare the behavior of rat bone marrow mesenchymal stem cells and rabbit auricle blastema cells implanted in non-cellular gingival tissue scaffold of human. In this regard, the tissues obtained from gingival… read more here.
Keywords: cell; gingival tissue; microscopy; blastema ... See more keywords
Morphogenic Effect of Exogenous Glucocorticoid Hormones in the Girardia tigrina Planarian (Turbellaria, Tricladida)
Sign Up to like & getrecommendations! Published in 2023 at "Biology"
DOI: 10.3390/biology12020292
Abstract: Simple Summary We have studied the effect of two glucocorticoid hormones: hydrocortisone and its synthetic analogue methylprednisolone on regeneration activity of Girardia tigrina planarian tissues. The results indicate that both hormones influence the recovery rate… read more here.
Keywords: tail blastema; regeneration; blastema; tigrina planarian ... See more keywords
A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.76987
Abstract: Regeneration depends on the ability of mature cells at the injury site to respond to injury, generating tissue-specific progenitors that incorporate the blastema and proliferate to reconstitute the original organ architecture. The metabolic microenvironment has… read more here.
Keywords: regeneration; cell; identity; blastema ... See more keywords